[HTML][HTML] Impairment of cerebral vascular reactivity and resting blood flow in early-staged transgenic AD mice: in vivo optical imaging studies
Background Alzheimer's disease (AD) is a neurodegenerative disorder with progressive
cognitive decline in aging individuals that poses a significant challenge to patients due to an …
cognitive decline in aging individuals that poses a significant challenge to patients due to an …
[HTML][HTML] Entorhinal cortex vulnerability to human APP expression promotes hyperexcitability and tau pathology
Preventative treatment for Alzheimer's Disease is of dire importance, and yet, cellular
mechanisms underlying early regional vulnerability in Alzheimer's Disease remain …
mechanisms underlying early regional vulnerability in Alzheimer's Disease remain …
Longitudinal analysis of the gut microbiome in the 5xfAD mouse model of Alzheimer's disease
SJB Dunham, KA McNair, ED Adams… - bioRxiv, 2022 - biorxiv.org
INTRODUCTION Microbial exposures impact Alzheimer's disease (AD), and a baseline
understanding of AD model microbiomes is vital for improving model efficacy. We describe …
understanding of AD model microbiomes is vital for improving model efficacy. We describe …
[PDF][PDF] AD 动物模型及其相关指标评价方法研究进展
谢晓露， 陈秀， 寇利秋， 李亚玲 - 中国比较医学杂志, 2022 - zgbjyx.cnjournals.com
阿尔兹海默病(Alzheimer's disease, AD) 是临床常见中枢神经系统退行性病变, 其病因不明,
病机不清, 并对患者家庭和社会造成了巨大负担. 成功建立一个符合人类疾病发生 …
病机不清, 并对患者家庭和社会造成了巨大负担. 成功建立一个符合人类疾病发生 …
Sex‐specific associations between AD genotype and the microbiome of human amyloid beta knock‐in (hAβ‐KI) mice
SJB Dunham, J Avelar‐Barragan… - Alzheimer's & …, 2024 - Wiley Online Library
INTRODUCTION Emerging evidence links changes in the gut microbiome to late‐onset
Alzheimer's disease (LOAD), necessitating examination of AD mouse models with …
Alzheimer's disease (LOAD), necessitating examination of AD mouse models with …
Positron emission tomography in animal models of Alzheimer's disease amyloidosis
R Ni - 2021 - preprints.org
Animal models of Alzheimer's disease amyloidosis that recapitulate cerebral amyloid-beta
pathology have been widely used in preclinical research, and have greatly enabled the …
pathology have been widely used in preclinical research, and have greatly enabled the …
The Neuroepigenetic landscape of vertebrate and invertebrate models of neurodegenerative diseases
TH Sundaramoorthy, I Castanho - Epigenetics Insights, 2022 - journals.sagepub.com
Vertebrate and invertebrate models of neurodegenerative diseases, such as Alzheimer's
disease, Parkinson's disease, and amyotrophic lateral sclerosis, have been paramount to …
disease, Parkinson's disease, and amyotrophic lateral sclerosis, have been paramount to …
APP-KI mice do not display the hallmark age-dependent cognitive decline of amyloid diseases
L Blackmer-Raynolds, LD Lipson, I Fraccaroli, IN Krout… - bioRxiv, 2024 - biorxiv.org
APP knock-in (KI) mice serve as an exciting new model system to understand amyloid beta
(Aβ) pathology, overcoming many of the limitations of previous overexpression-based model …
(Aβ) pathology, overcoming many of the limitations of previous overexpression-based model …
Transcriptomic similarities and differences between mouse models and human Alzheimer's Disease
MA De Bastiani, B Bellaver, G Carello-Collar… - bioRxiv, 2021 - biorxiv.org
Alzheimer's disease (AD) is a multifactorial pathology responsible for most cases of
dementia worldwide. Only a small percentage of AD cases are due to autosomal dominant …
dementia worldwide. Only a small percentage of AD cases are due to autosomal dominant …
An isogenic panel of single App knock-in mouse models of Alzheimer's disease confers differential profiles of β-secretase inhibition and endosomal abnormalities
N Watamura, K Sato, G Shiihashi, A Iwasaki… - bioRxiv, 2021 - biorxiv.org
We previously developed single App knock-in mouse models of Alzheimer's disease (AD)
that harbor the Swedish and Beyreuther/Iberian mutations with or without the Arctic mutation …
that harbor the Swedish and Beyreuther/Iberian mutations with or without the Arctic mutation …