[HTML][HTML] PI3K/Akt/mTOR pathway and its role in cancer therapeutics: are we making headway?
Y Peng, Y Wang, C Zhou, W Mei, C Zeng - Frontiers in oncology, 2022 - frontiersin.org
Cancer is a severe public health issue that is a leading cause of mortality globally. It is also
an impediment to improving life expectancy worldwide. Furthermore, the global burden of …
an impediment to improving life expectancy worldwide. Furthermore, the global burden of …
[HTML][HTML] Signaling pathways and therapeutic interventions in gastric cancer
Gastric cancer (GC) ranks fifth in global cancer diagnosis and fourth in cancer-related death.
Despite tremendous progress in diagnosis and therapeutic strategies and significant …
Despite tremendous progress in diagnosis and therapeutic strategies and significant …
Oxidative stress in intervertebral disc degeneration: molecular mechanisms, pathogenesis and treatment
Y Wang, H Cheng, T Wang, K Zhang, Y Zhang… - Cell …, 2023 - Wiley Online Library
Low back pain (LBP) is a leading cause of labour loss and disability worldwide, and it also
imposes a severe economic burden on patients and society. Among symptomatic LBP …
imposes a severe economic burden on patients and society. Among symptomatic LBP …
[HTML][HTML] Targeted therapy and mechanisms of drug resistance in breast cancer
Simple Summary Internationally, in women, breast cancer (BC) is the most common cancer
type and is the leading cause of cancer-related death. There are two main histological …
type and is the leading cause of cancer-related death. There are two main histological …
[HTML][HTML] Breast cancer stem-like cells in drug resistance: a review of mechanisms and novel therapeutic strategies to overcome drug resistance
Breast cancer is the most frequent type of malignancy in women worldwide, and drug
resistance to the available systemic therapies remains a major challenge. At the molecular …
resistance to the available systemic therapies remains a major challenge. At the molecular …
[HTML][HTML] Biologically synthesized black ginger-selenium nanoparticle induces apoptosis and autophagy of AGS gastric cancer cells by suppressing the PI3K/Akt/mTOR …
Background Despite being a promising strategy, current chemotherapy for gastric cancer
(GC) is limited due to adverse side effects and poor survival rates. Therefore, new drug …
(GC) is limited due to adverse side effects and poor survival rates. Therefore, new drug …
[HTML][HTML] PIK3CA-mutations in breast cancer
K Reinhardt, K Stückrath, C Hartung, S Kaufhold… - Breast Cancer Research …, 2022 - Springer
Abstract Purpose Phosphatidylinositide-3-kinase (PI3K) regulates proliferation and
apoptosis; somatic PIK3CA-mutations may activate these processes. Aim of this study was to …
apoptosis; somatic PIK3CA-mutations may activate these processes. Aim of this study was to …
[HTML][HTML] Targeting breast cancer: An overlook on current strategies
D Iacopetta, J Ceramella, N Baldino… - International Journal of …, 2023 - mdpi.com
Breast cancer (BC) is one of the most widely diagnosed cancers and a leading cause of
cancer death among women worldwide. Globally, BC is the second most frequent cancer …
cancer death among women worldwide. Globally, BC is the second most frequent cancer …
[HTML][HTML] Promoting apoptosis, a promising way to treat breast cancer with natural products: A comprehensive review
L Yuan, Y Cai, L Zhang, S Liu, P Li, X Li - Frontiers in pharmacology, 2022 - frontiersin.org
Breast cancer is one of the top-ranked malignant carcinomas associated with morbidity and
mortality in women worldwide. Chemotherapy is one of the main approaches to breast …
mortality in women worldwide. Chemotherapy is one of the main approaches to breast …
Targeting PI3K/Akt signaling in prostate cancer therapy
M Hashemi, A Taheriazam, P Daneii… - Journal of Cell …, 2023 - Springer
Urological cancers have obtained much attention in recent years due to their mortality and
morbidity. The most common and malignant tumor of urological cancers is prostate cancer …
morbidity. The most common and malignant tumor of urological cancers is prostate cancer …