[HTML][HTML] PI3K/Akt/mTOR pathway and its role in cancer therapeutics: are we making headway?

Y Peng, Y Wang, C Zhou, W Mei, C Zeng - Frontiers in oncology, 2022 - frontiersin.org
Cancer is a severe public health issue that is a leading cause of mortality globally. It is also
an impediment to improving life expectancy worldwide. Furthermore, the global burden of …

[HTML][HTML] Signaling pathways and therapeutic interventions in gastric cancer

ZN Lei, QX Teng, Q Tian, W Chen, Y Xie… - Signal transduction and …, 2022 - nature.com
Gastric cancer (GC) ranks fifth in global cancer diagnosis and fourth in cancer-related death.
Despite tremendous progress in diagnosis and therapeutic strategies and significant …

Oxidative stress in intervertebral disc degeneration: molecular mechanisms, pathogenesis and treatment

Y Wang, H Cheng, T Wang, K Zhang, Y Zhang… - Cell …, 2023 - Wiley Online Library
Low back pain (LBP) is a leading cause of labour loss and disability worldwide, and it also
imposes a severe economic burden on patients and society. Among symptomatic LBP …

[HTML][HTML] Targeted therapy and mechanisms of drug resistance in breast cancer

B Kinnel, SK Singh, G Oprea-Ilies, R Singh - Cancers, 2023 - mdpi.com
Simple Summary Internationally, in women, breast cancer (BC) is the most common cancer
type and is the leading cause of cancer-related death. There are two main histological …

[HTML][HTML] Breast cancer stem-like cells in drug resistance: a review of mechanisms and novel therapeutic strategies to overcome drug resistance

T Saha, KE Lukong - Frontiers in oncology, 2022 - frontiersin.org
Breast cancer is the most frequent type of malignancy in women worldwide, and drug
resistance to the available systemic therapies remains a major challenge. At the molecular …

[HTML][HTML] Biologically synthesized black ginger-selenium nanoparticle induces apoptosis and autophagy of AGS gastric cancer cells by suppressing the PI3K/Akt/mTOR …

R Wang, K Ha, S Dhandapani, YJ Kim - Journal of nanobiotechnology, 2022 - Springer
Background Despite being a promising strategy, current chemotherapy for gastric cancer
(GC) is limited due to adverse side effects and poor survival rates. Therefore, new drug …

[HTML][HTML] PIK3CA-mutations in breast cancer

K Reinhardt, K Stückrath, C Hartung, S Kaufhold… - Breast Cancer Research …, 2022 - Springer
Abstract Purpose Phosphatidylinositide-3-kinase (PI3K) regulates proliferation and
apoptosis; somatic PIK3CA-mutations may activate these processes. Aim of this study was to …

[HTML][HTML] Targeting breast cancer: An overlook on current strategies

D Iacopetta, J Ceramella, N Baldino… - International Journal of …, 2023 - mdpi.com
Breast cancer (BC) is one of the most widely diagnosed cancers and a leading cause of
cancer death among women worldwide. Globally, BC is the second most frequent cancer …

[HTML][HTML] Promoting apoptosis, a promising way to treat breast cancer with natural products: A comprehensive review

L Yuan, Y Cai, L Zhang, S Liu, P Li, X Li - Frontiers in pharmacology, 2022 - frontiersin.org
Breast cancer is one of the top-ranked malignant carcinomas associated with morbidity and
mortality in women worldwide. Chemotherapy is one of the main approaches to breast …

Targeting PI3K/Akt signaling in prostate cancer therapy

M Hashemi, A Taheriazam, P Daneii… - Journal of Cell …, 2023 - Springer
Urological cancers have obtained much attention in recent years due to their mortality and
morbidity. The most common and malignant tumor of urological cancers is prostate cancer …