Role of the gut–brain axis in energy and glucose metabolism

HR Wachsmuth, SN Weninger, FA Duca - Experimental & molecular …, 2022 - nature.com
The gastrointestinal tract plays a role in the development and treatment of metabolic
diseases. During a meal, the gut provides crucial information to the brain regarding …

Signaling pathways in obesity: mechanisms and therapeutic interventions

X Wen, B Zhang, B Wu, H Xiao, Z Li, R Li… - Signal transduction and …, 2022 - nature.com
Obesity is a complex, chronic disease and global public health challenge. Characterized by
excessive fat accumulation in the body, obesity sharply increases the risk of several …

A comprehensive review on emerging artificial neuromorphic devices

J Zhu, T Zhang, Y Yang, R Huang - Applied Physics Reviews, 2020 - pubs.aip.org
The rapid development of information technology has led to urgent requirements for high
efficiency and ultralow power consumption. In the past few decades, neuromorphic …

Adipocyte regulation of insulin sensitivity and the risk of type 2 diabetes

A Santoro, BB Kahn - New England Journal of Medicine, 2023 - Mass Medical Soc
Adipocyte Regulation of Insulin Sensitivity and the Risk of Type 2 Diabetes | NEJM Skip to main
content NEJM Group Follow Us Facebook Twitter Instagram YouTube LinkedIn Prepare to …

Leptin, obesity, and leptin resistance: where are we 25 years later?

AG Izquierdo, AB Crujeiras, FF Casanueva… - Nutrients, 2019 - mdpi.com
Leptin, a hormone that is capable of effectively reducing food intake and body weight, was
initially considered for use in the treatment of obesity. However, obese subjects have since …

Obesity, kidney dysfunction and hypertension: mechanistic links

JE Hall, JM do Carmo, AA da Silva, Z Wang… - Nature reviews …, 2019 - nature.com
Excessive adiposity raises blood pressure and accounts for 65–75% of primary
hypertension, which is a major driver of cardiovascular and kidney diseases. In obesity …

[HTML][HTML] Adipokines: new potential therapeutic target for obesity and metabolic, rheumatic, and cardiovascular diseases

L Recinella, G Orlando, C Ferrante… - Frontiers in …, 2020 - frontiersin.org
Besides its role as an energy storage organ, adipose tissue can be viewed as a dynamic
and complex endocrine organ, which produces and secretes several adipokines, including …

Stress and obesity

AJ Tomiyama - Annual review of psychology, 2019 - annualreviews.org
Many pathways connect stress and obesity, two highly prevalent problems facing society
today. First, stress interferes with cognitive processes such as executive function and self …

The cell biology of systemic insulin function

VL Tokarz, PE MacDonald, A Klip - Journal of Cell Biology, 2018 - rupress.org
Insulin is the paramount anabolic hormone, promoting carbon energy deposition in the
body. Its synthesis, quality control, delivery, and action are exquisitely regulated by highly …

[HTML][HTML] Metabolism disrupting chemicals and metabolic disorders

JJ Heindel, B Blumberg, M Cave, R Machtinger… - Reproductive …, 2017 - Elsevier
The recent epidemics of metabolic diseases, obesity, type 2 diabetes (T2D), liver lipid
disorders and metabolic syndrome have largely been attributed to genetic background and …