A Hybrid drug which comprises the incorporation of two drug pharmacophores in one single
molecule are basically designed to interact with multiple targets or to amplify its effect …

Kinesins are a family of molecular motors that travel unidirectionally along microtubule
tracks to fulfil their many roles in intracellular transport or cell division. Over the past few …

Acclaimed by the worldwide medical community as" a staple reference text in the medical
oncologist's library"(JAMA), DeVita, Hellman, and Rosenberg's Cancer: Principles and …

Marine secondary metabolites are a promising source of unexploited drugs that have a wide
structural diversity and have shown a variety of biological activities. These compounds are …

Tumour cells undergo uncontrolled proliferation, yet tumours most often originate from adult
tissues, in which most cells are quiescent. So, the proliferative advantage of tumour cells …

Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment
from the point of view of medicinal chemistry and drug design, focusing on the mechanism of …

The advent of molecularly targeted drug discovery has facilitated the identification of a new
generation of anti-mitotic therapies that target proteins with specific functions in mitosis. The …

Background: Gene expression profiling data for human primary cutaneous melanomas are
scarce because of the lack of retrospective collections of frozen tumors. To identify …

The toxicity of cancer chemotherapy is among the most important factors limiting its use.
Clear delineation and communication of benefits and risks is an essential component of …

In creating the mitotic spindle and the contractile ring, natural selection has engineered
fascinating precision machines whose movements depend upon forces generated by …