Erythrocytes (RBCs) represent the main cell component in circulation and recently have
become a topic of intensive scientific interest. The relevance of erythrocytes as a model for …

We review the use of molecular dynamics (MD) simulation as a drug design tool in the
context of the role that the lipid membrane can play in drug action, ie, the interaction …

Background: Desipramine a representative of tricyclic antidepressants (TCAs) promotes
recovery of depressed patients by inhibition of reuptake of neurotransmitters serotonin …

Aβ (1-42) peptide is a neurotoxic agent strongly associated with the etiology of Alzheimer's
disease (AD). Current treatments are still of very low effectiveness, and deaths from AD are …

Using the electron paramagnetic resonance (EPR) of spin-labeled stearic acid and a spin
label chemically attached to the membrane proteins, the interaction of miltefosine (MIL) and …

For miltefosine (MIL), a zwitterionic alkylphospholipid approved for leishmaniasis treatment,
the mechanism of action is not well established. Electron paramagnetic resonance (EPR) …

Epirubicin is a cytotoxic drug used in the treatment of different types of cancer and
increasing evidence suggests that its target is cell membranes. In order to gain insight on its …

Abstract Miltefosine (MLT, hexadecylphosphocholine (HePC)) is an alkylphospholipid (APL)
clinically used against leishmaniasis and the topical treatment of cancer. Although the MLT …

Alkylphospholipids are a novel class of antineoplastic drugs showing remarkable
therapeutic potential. Among them, erufosine (EPC3) is a promising drug for the treatment of …

The hematological impacts of a drug can affect erythropoiesis at the level of the bone
marrow, or decrease the life span of the RBC (red blood cell). The most common and …