With the emergence of CRISPR technology, targeted editing of a wide variety of genomes is
no longer an abstract hypothetical, but occurs regularly. As application areas of CRISPR are …

A recurrent theme in evolutionary biology is to contrast natural selection and developmental
constraint–two forces pitted against each other as competing explanations for organismal …

Skates are cartilaginous fish whose body plan features enlarged wing-like pectoral fins,
enabling them to thrive in benthic environments,. However, the molecular underpinnings of …

Wild animals and plants have developed a variety of adaptive traits driven by adaptive
evolution, an important strategy for species survival and persistence. Uncovering the …

Deciphering the evolutionary relationships of Chelicerata (arachnids, horseshoe crabs, and
allied taxa) has proven notoriously difficult, due to their ancient rapid radiation and the …

The limb is a commonly used model system for developmental biology. Given the need for
precise control of complex signalling pathways to achieve proper patterning, the limb is also …

Oncogenic alterations to DNA are not transforming in all cellular contexts,. This may be due
to pre-existing transcriptional programmes in the cell of origin. Here we define anatomic …

Since their discovery Hox genes have been at the core of the established models explaining
the development and evolution of the vertebrate body plan as well as its paired …

The iconic phenotype of seadragons includes leaf-like appendages, a toothless tubular
mouth, and male pregnancy involving incubation of fertilized eggs on an open “brood patch.” …

A central topic in research at the intersection of development and evolution is the origin of
novel traits. Despite progress on understanding how developmental mechanisms underlie …