Glycoconjugates: synthesis, functional studies, and therapeutic developments
Glycoconjugates are major constituents of mammalian cells that are formed via covalent
conjugation of carbohydrates to other biomolecules like proteins and lipids and often …
conjugation of carbohydrates to other biomolecules like proteins and lipids and often …
The Notch signaling pathway: a potential target for cancer immunotherapy
Dysregulation of the Notch signaling pathway, which is highly conserved across species,
can drive aberrant epigenetic modification, transcription, and translation. Defective gene …
can drive aberrant epigenetic modification, transcription, and translation. Defective gene …
DNA vaccines—how far from clinical use?
D Hobernik, M Bros - International journal of molecular sciences, 2018 - mdpi.com
Two decades ago successful transfection of antigen presenting cells (APC) in vivo was
demonstrated which resulted in the induction of primary adaptive immune responses. Due to …
demonstrated which resulted in the induction of primary adaptive immune responses. Due to …
Significance and implications of FDA approval of pembrolizumab for biomarker-defined disease
MM Boyiadzis, JM Kirkwood, JL Marshall… - … for immunotherapy of …, 2018 - Springer
Abstract The US Food and Drug Administration (FDA) recently approved pembrolizumab, an
anti-programmed cell death protein 1 cancer immunotherapeutic, for use in advanced solid …
anti-programmed cell death protein 1 cancer immunotherapeutic, for use in advanced solid …
Impaired inflammatory state of the endometrium: a multifaceted approach to endometrial inflammation. Current insights and future directions
A Drizi, D Djokovic, AS Laganà… - Menopause Review …, 2020 - termedia.pl
Methods A non-systematic review was done through a search on the following databases:
MEDLINE, EMBASE, Global Health, The Cochrane Library (Cochrane Database of …
MEDLINE, EMBASE, Global Health, The Cochrane Library (Cochrane Database of …
Overview of recent advances in liposomal nanoparticle-based cancer immunotherapy
The clinical performance of conventional cancer therapy approaches (surgery, radiotherapy,
and chemotherapy) has been challenged by tumor metastasis and recurrence that is mainly …
and chemotherapy) has been challenged by tumor metastasis and recurrence that is mainly …
Immunogenicity of protein pharmaceuticals
R Dingman, SV Balu-Iyer - Journal of pharmaceutical sciences, 2019 - Elsevier
Protein therapeutics have drastically changed the landscape of treatment for many diseases
by providing a regimen that is highly specific and lacks many off-target toxicities. The clinical …
by providing a regimen that is highly specific and lacks many off-target toxicities. The clinical …
[HTML][HTML] Vaccine development: From concept to early clinical testing
AL Cunningham, N Garçon, O Leo, LR Friedland… - Vaccine, 2016 - Elsevier
In the 21st century, an array of microbiological and molecular allow antigens for new
vaccines to be specifically identified, designed, produced and delivered with the aim of …
vaccines to be specifically identified, designed, produced and delivered with the aim of …
Synergistic immunostimulatory effects and therapeutic benefit of combined histone deacetylase and bromodomain inhibition in non–small cell lung cancer
DO Adeegbe, Y Liu, PH Lizotte, Y Kamihara, AR Aref… - Cancer discovery, 2017 - AACR
Effective therapies for non–small cell lung cancer (NSCLC) remain challenging despite an
increasingly comprehensive understanding of somatically altered oncogenic pathways. It is …
increasingly comprehensive understanding of somatically altered oncogenic pathways. It is …
Self-adjuvanted nanovaccine for cancer immunotherapy: Role of lysosomal rupture-induced ROS in MHC class I antigen presentation
Abstract MHC class I (MHC I) antigen presentation of exogenous antigens (so called “cross
presentation”) is a central mechanism of CD8+ cytotoxic T lymphocyte (CTL) responses …
presentation”) is a central mechanism of CD8+ cytotoxic T lymphocyte (CTL) responses …