Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) are a
family of small conserved eukaryotic proteins that mediate membrane fusion between …

Abstract α-Synuclein is a neuronal protein that is enriched in presynaptic terminals. Under
physiological conditions, it binds to synaptic vesicle membranes and functions in …

Lipid nanoparticles (LNPs) have emerged as potent carriers for mRNA delivery, but several
challenges remain before this approach can offer broad clinical translation of mRNA …

Membrane fusion is a key process in all living organisms that contributes to a variety of
biological processes including viral infection, cell fertilization, as well as intracellular …

Soluble N-ethylmaleimide–sensitive factor attachment protein receptor (SNARE) proteins
drive membrane fusion by assembling into a four-helix bundle in a zippering process. Here …

Neurotransmitter release is governed by proteins that have homo-logs in most types of
intracellular membrane fusion, including the Sec1/Munc18 protein Munc18-1 and the …

SNAREs are the core machinery mediating membrane fusion. In this review, we provide an
update on the recent progress on SNAREs regulating membrane fusion events, especially …

Exocytosis requires formation of SNARE [soluble N-ethylmaleimide–sensitive factor
attachment protein (SNAP) receptor] complexes between vesicle and target membranes …

Neurotransmitters are released through nascent fusion pores, which ordinarily dilate after
bilayer fusion, preventing consistent biochemical studies. We used lipid bilayer nanodiscs …

Controlled release of neurotransmitters stored in synaptic vesicles (SVs) is a fundamental
process that is central to all information processing in the brain. This relies on tight coupling …