A review of the microbial production of bioactive natural products and biologics

JV Pham, MA Yilma, A Feliz, MT Majid… - Frontiers in …, 2019 - frontiersin.org
A variety of organisms, such as bacteria, fungi, and plants, produce secondary metabolites,
also known as natural products. Natural products have been a prolific source and an …

In vitro plant tissue culture: means for production of biological active compounds

CA Espinosa-Leal, CA Puente-Garza, S García-Lara - Planta, 2018 - Springer
Main conclusion Plant tissue culture as an important tool for the continuous production of
active compounds including secondary metabolites and engineered molecules. Novel …

A metabolic pathway for bile acid dehydroxylation by the gut microbiome

M Funabashi, TL Grove, M Wang, Y Varma… - Nature, 2020 - nature.com
The gut microbiota synthesize hundreds of molecules, many of which influence host
physiology. Among the most abundant metabolites are the secondary bile acids deoxycholic …

[HTML][HTML] Fermentation-enabled wellness foods: A fresh perspective

H Xiang, D Sun-Waterhouse, GIN Waterhouse… - Food Science and …, 2019 - Elsevier
Fermented foods represent an important segment of current food markets, especially
traditional or ethnic food markets. The demand for efficient utilization of agrowastes, together …

[HTML][HTML] Actinobacteria in natural products research: Progress and prospects

PA Jose, A Maharshi, B Jha - Microbiological research, 2021 - Elsevier
Actinobacteria are well-recognised biosynthetic factories that produce an extensive
spectrum of secondary metabolites. Recent genomic insights seem to impact the exploitation …

Recent advances in systems and synthetic biology approaches for developing novel cell-factories in non-conventional yeasts

P Patra, M Das, P Kundu, A Ghosh - Biotechnology Advances, 2021 - Elsevier
Microbial bioproduction of chemicals, proteins, and primary metabolites from cheap carbon
sources is currently an advancing area in industrial research. The model yeast …

Lignans of Sesame (Sesamum indicum L.): A Comprehensive Review

M Andargie, M Vinas, A Rathgeb, E Möller, P Karlovsky - Molecules, 2021 - mdpi.com
Major lignans of sesame sesamin and sesamolin are benzodioxol--substituted furofurans.
Sesamol, sesaminol, its epimers, and episesamin are transformation products found in …

Synthetic biology to access and expand nature's chemical diversity

MJ Smanski, H Zhou, J Claesen, B Shen… - Nature Reviews …, 2016 - nature.com
Bacterial genomes encode the biosynthetic potential to produce hundreds of thousands of
complex molecules with diverse applications, from medicine to agriculture and materials …

De novo production of the plant-derived alkaloid strictosidine in yeast

S Brown, M Clastre, V Courdavault… - Proceedings of the …, 2015 - National Acad Sciences
The monoterpene indole alkaloids are a large group of plant-derived specialized
metabolites, many of which have valuable pharmaceutical or biological activity. There are∼ …

Thoughts and facts about antibiotics: where we are now and where we are heading

J Bérdy - The Journal of antibiotics, 2012 - nature.com
The declining trends in microbial metabolite and natural products research and the
refocusing of this research area are discussed. Renewing natural products research …