Fluid transport in the brain

MK Rasmussen, H Mestre… - Physiological …, 2022 - journals.physiology.org
The brain harbors a unique ability to, figuratively speaking, shift its gears. During
wakefulness, the brain is geared fully toward processing information and behaving, while …

History and progress of hypotheses and clinical trials for Alzheimer's disease

PP Liu, Y Xie, XY Meng, JS Kang - Signal transduction and targeted …, 2019 - nature.com
Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive
memory loss along with neuropsychiatric symptoms and a decline in activities of daily life. Its …

[PDF][PDF] VEGF in signaling and disease: beyond discovery and development

RS Apte, DS Chen, N Ferrara - Cell, 2019 - cell.com
The discovery of vascular endothelial-derived growth factor (VEGF) has revolutionized our
understanding of vasculogenesis and angiogenesis during development and physiological …

Exosomal long noncoding RNA LNMAT2 promotes lymphatic metastasis in bladder cancer

C Chen, Y Luo, W He, Y Zhao, Y Kong… - The Journal of …, 2020 - Am Soc Clin Investig
Patients with bladder cancer (BCa) with clinical lymph node (LN) metastasis have an
extremely poor prognosis. VEGF-C has been demonstrated to play vital roles in LN …

Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI

M Absinta, SK Ha, G Nair, P Sati, NJ Luciano… - elife, 2017 - elifesciences.org
Here, we report the existence of meningeal lymphatic vessels in human and nonhuman
primates (common marmoset monkeys) and the feasibility of noninvasively imaging and …

Signaling pathways and targeted therapies in lung squamous cell carcinoma: mechanisms and clinical trials

Z Niu, R Jin, Y Zhang, H Li - Signal Transduction and Targeted Therapy, 2022 - nature.com
Lung cancer is the leading cause of cancer-related death across the world. Unlike lung
adenocarcinoma, patients with lung squamous cell carcinoma (LSCC) have not benefitted …

[PDF][PDF] The meningeal lymphatic system: a new player in neurophysiology

S Da Mesquita, Z Fu, J Kipnis - Neuron, 2018 - cell.com
The nature of fluid dynamics within the brain parenchyma is a focus of intensive research. Of
particular relevance is its participation in diseases associated with protein accumulation and …

Complexation-induced resolution enhancement of 3D-printed hydrogel constructs

J Gong, CCL Schuurmans, AM Genderen… - Nature …, 2020 - nature.com
Abstract Three-dimensional (3D) hydrogel printing enables production of volumetric
architectures containing desired structures using programmed automation processes. Our …

Immunopathogenesis of IBD: current state of the art

HSP De Souza, C Fiocchi - Nature reviews Gastroenterology & …, 2016 - nature.com
IBD is a chronic inflammatory condition of the gastrointestinal tract encompassing two main
clinical entities: Crohn's disease and ulcerative colitis. Although Crohn's disease and …

Ten years of anti-vascular endothelial growth factor therapy

N Ferrara, AP Adamis - Nature reviews Drug discovery, 2016 - nature.com
The targeting of vascular endothelial growth factor A (VEGFA), a crucial regulator of both
normal and pathological angiogenesis, has revealed innovative therapeutic approaches in …