Adjuvant or early salvage radiotherapy for the treatment of localised and locally advanced prostate cancer: a prospectively planned systematic review and meta …

CL Vale, D Fisher, A Kneebone, C Parker, M Pearse… - The Lancet, 2020 - thelancet.com
Background It is unclear whether adjuvant or early salvage radiotherapy following radical
prostatectomy is more appropriate for men who present with localised or locally advanced …

High-risk prostate cancer—classification and therapy

AJ Chang, KA Autio, M Roach III, HI Scher - Nature reviews Clinical …, 2014 - nature.com
Approximately 15% of patients with prostate cancer are diagnosed with high-risk disease.
However, the current definitions of high-risk prostate cancer include a heterogeneous group …

Clinically localized prostate cancer: AUA/ASTRO guideline, part I: introduction, risk assessment, staging, and risk-based management

JA Eastham, GB Auffenberg, DA Barocas… - The Journal of …, 2022 - auajournals.org
Purpose: The summary presented herein represents Part I of the three-part series dedicated
to Clinically Localized Prostate Cancer: AUA/ASTRO Guideline, discussing risk assessment …

Focal boost to the intraprostatic tumor in external beam radiotherapy for patients with localized prostate cancer: results from the FLAME randomized phase III trial

LGW Kerkmeijer, VH Groen, FJ Pos… - Journal of Clinical …, 2021 - ascopubs.org
PURPOSE This study investigates whether focal boosting of the macroscopic visible tumor
with external beam radiotherapy increases biochemical disease-free survival (bDFS) in …

Timing of radiotherapy after radical prostatectomy (RADICALS-RT): a randomised, controlled phase 3 trial

CC Parker, NW Clarke, AD Cook, HG Kynaston… - The Lancet, 2020 - thelancet.com
Background The optimal timing of radiotherapy after radical prostatectomy for prostate
cancer is uncertain. We aimed to compare the efficacy and safety of adjuvant radiotherapy …

Advanced prostate cancer: AUA/ASTRO/SUO guideline part I

WT Lowrance, RH Breau, R Chou, BF Chapin… - The Journal of …, 2021 - auajournals.org
Purpose: The summary presented herein represents Part I of the two-part series dedicated to
Advanced Prostate Cancer: AUA/ASTRO/SUO Guideline discussing prognostic and …

Development and validation of a novel integrated clinical-genomic risk group classification for localized prostate cancer

DE Spratt, J Zhang, M Santiago-Jiménez… - Journal of Clinical …, 2018 - ascopubs.org
Purpose It is clinically challenging to integrate genomic-classifier results that report a
numeric risk of recurrence into treatment recommendations for localized prostate cancer …

The immune landscape of prostate cancer and nomination of PD-L2 as a potential therapeutic target

SG Zhao, J Lehrer, SL Chang, R Das… - JNCI: Journal of the …, 2019 - academic.oup.com
Background Immunotherapy has been less successful in treating prostate cancer than other
solid tumors. We sought to better understand the immune landscape in prostate cancer and …

Tissue-based genomics augments post-prostatectomy risk stratification in a natural history cohort of intermediate-and high-risk men

AE Ross, MH Johnson, K Yousefi, E Davicioni… - European urology, 2016 - Elsevier
Background Radical prostatectomy (RP) is a primary treatment option for men with
intermediate-and high-risk prostate cancer. Although many are effectively cured with local …

Validation of a genomic classifier that predicts metastasis following radical prostatectomy in an at risk patient population

RJ Karnes, EJ Bergstralh, E Davicioni… - The Journal of …, 2013 - auajournals.org
Purpose: Patients with locally advanced prostate cancer after radical prostatectomy are
candidates for secondary therapy. However, this higher risk population is heterogeneous …