[HTML][HTML] Multiple sclerosis: role of meningeal lymphoid aggregates in progression independent of relapse activity

RM Ransohoff - Trends in Immunology, 2023 - cell.com
The emphasis on mechanisms driving multiple sclerosis (MS) symptomatic worsening
suggests that we move beyond categorical clinical classifiers such as relapsing–remitting …

[HTML][HTML] Identification and management of subclinical disease activity in early multiple sclerosis: a review

D Ontaneda, T Chitnis, K Rammohan, AZ Obeidat - Journal of Neurology, 2024 - Springer
Importance Early treatment initiation in multiple sclerosis (MS) is crucial in preventing
irreversible neurological damage and disability progression. The current assessment of …

[HTML][HTML] Role of Selenium in Pathogenesis and Treatment of the Autoimmune Diseases

E Rahmani, AM Fard, H Baghsheikhi, Z Hosseini… - Kindle, 2022 - preferpub.org
In vitro investigations have revealed that consumption of selenium can considerably
decrease the expression of IFN-g in Th1 cells. A low plasma selenium content has been …

[HTML][HTML] Personalized use of disease-modifying therapies in multiple sclerosis

CY Lee, KH Chan - Pharmaceutics, 2024 - mdpi.com
Multiple sclerosis is an important neurological disease affecting millions of young patients
globally. It is encouraging that more than ten disease-modifying drugs became available for …

[HTML][HTML] No evidence of disease activity (NEDA) as a clinical assessment tool for multiple sclerosis: Clinician and patient perspectives [Narrative Review]

SD Newsome, C Binns, UW Kaunzner, S Morgan… - Neurology and …, 2023 - Springer
The emergence of high-efficacy therapies for multiple sclerosis (MS), which target
inflammation more effectively than traditional disease-modifying therapies, has led to a shift …

[HTML][HTML] Early use of high-efficacy therapies in multiple sclerosis in the United States: benefits, barriers, and strategies for encouraging adoption

BA Singer, J Feng, H Chiong-Rivero - Journal of Neurology, 2024 - Springer
Multiple sclerosis (MS) is characterized by progressive neuroinflammation and
neurodegeneration from disease onset that, if left untreated, can result in the accumulation …

Safety and efficacy with alemtuzumab over 13 years in relapsing-remitting multiple sclerosis: final results from the open-label TOPAZ study

AJ Coles, A Achiron, A Traboulsee… - Therapeutic …, 2023 - journals.sagepub.com
Background and objectives: Alemtuzumab demonstrated superior efficacy versus
subcutaneous interferon (IFN) beta-1a in participants with relapsing-remitting multiple …

[HTML][HTML] Magnetic Resonance Imaging Evidence Supporting the Efficacy of Cladribine Tablets in the Treatment of Relapsing-Remitting Multiple Sclerosis

R Cortese, G Testa, F Assogna, N De Stefano - CNS drugs, 2024 - Springer
Numerous therapies are currently available to modify the disease course of multiple
sclerosis (MS). Magnetic resonance imaging (MRI) plays a pivotal role in assessing …

[HTML][HTML] Dimethyl fumarate treatment in relapsing remitting MS changes the inflammatory CSF protein profile by a prominent decrease in T-helper 1 immunity

S Hojjati, J Ernerudh, M Vrethem, J Mellergård… - Multiple Sclerosis and …, 2023 - Elsevier
Background Dimethyl fumarate (DMF) is a common treatment for multiple sclerosis (MS), but
its mechanisms of action are not fully understood. Targeted proteomics offers insights into …

[HTML][HTML] Graphene oxide films as a novel tool for the modulation of myeloid-derived suppressor cell activity in the context of multiple sclerosis

C Camacho-Toledano, I Machín-Díaz, R Lebrón-Galán… - Nanoscale, 2024 - pubs.rsc.org
Despite the pharmacological arsenal approved for Multiple Sclerosis (MS), there are
treatment-reluctant patients for whom cell therapy appears as the only therapeutic …