Overexpression of P-glycoprotein (P-gp) is one of the major problems to successful cancer
chemotherapy. To find novel effective P-gp inhibitors, a series of bifendate–chalcone hybrids …

The development of copper (II) thiosemicarbazone complexes as potential anticancer
agents, possessing dual functionality as inhibitors of R2 ribonucleotide reductase (RNR) …

Three novel pyrimidinylhydrazones substituted at either the aromatic moiety or at the imine
carbon atom were synthesized and characterized by standard analytical methods. All …

The resistance of tumors against anticancer drugs is a major impediment for chemotherapy.
Tumors often develop multidrug resistance as a result of the cellular efflux of …

A novel series of P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) inhibitors with
triazol-N-phenethyl-tetrahydroisoquinoline or triazol-N-ethyl-tetrahydroisoquinoline scaffold …

Filoviruses such as Ebola (EBOV) and Marburg (MARV) are single-stranded negative sense
RNA viruses that cause acute hemorrhagic fever with high mortality rates. Currently, there …

The rapidly growing area of catalytic ruthenium chemistry has provided new complexes with
potential as organometallic anticancer agents with novel mechanisms of action. Here we …

With the aim to incorporate pharmacophore motifs into the Ru (II)-polypyridyl framework,
compounds [Ru (II)(1, 10-phenantroline) 2 (2-(2-pyridyl) benzo [b] thiophene)](CF 3 SO 3) 2 …

Isatin is a well acknowledged pharmacophore in many clinically approved drugs used for
treatment of cancer. 3-Hydrazinoindolin-2-one, as a derivative of isatin, represents a …

Simple Summary Effective treatment of cancer is often limited by the resistance of cancer
cells to chemotherapy. A well-described mechanism supporting multidrug resistance (MDR) …