Synthesis and biological evaluation of bifendate–chalcone hybrids as a new class of potential P-glycoprotein inhibitors
X Gu, Z Ren, X Tang, H Peng, Y Ma, Y Lai… - Bioorganic & medicinal …, 2012 - Elsevier
Overexpression of P-glycoprotein (P-gp) is one of the major problems to successful cancer
chemotherapy. To find novel effective P-gp inhibitors, a series of bifendate–chalcone hybrids …
chemotherapy. To find novel effective P-gp inhibitors, a series of bifendate–chalcone hybrids …
Copper (II) Complexes with Isomeric Morpholine-Substituted 2-Formylpyridine Thiosemicarbazone Hybrids as Potential Anticancer Drugs Inhibiting Both …
MNM Milunovic, K Ohui, I Besleaga… - Journal of Medicinal …, 2024 - ACS Publications
The development of copper (II) thiosemicarbazone complexes as potential anticancer
agents, possessing dual functionality as inhibitors of R2 ribonucleotide reductase (RNR) …
agents, possessing dual functionality as inhibitors of R2 ribonucleotide reductase (RNR) …
[HTML][HTML] Synthesis and characterization of the anticancer and metal binding properties of novel pyrimidinylhydrazone derivatives
Three novel pyrimidinylhydrazones substituted at either the aromatic moiety or at the imine
carbon atom were synthesized and characterized by standard analytical methods. All …
carbon atom were synthesized and characterized by standard analytical methods. All …
[HTML][HTML] Synthesis and anticancer cytotoxicity of azaaurones overcoming multidrug resistance
The resistance of tumors against anticancer drugs is a major impediment for chemotherapy.
Tumors often develop multidrug resistance as a result of the cellular efflux of …
Tumors often develop multidrug resistance as a result of the cellular efflux of …
Design, synthesis and biological evaluation of LBM-A5 derivatives as potent P-glycoprotein-mediated multidrug resistance inhibitors
Y Wu, M Pan, Y Dai, B Liu, J Cui, W Shi, Q Qiu… - Bioorganic & Medicinal …, 2016 - Elsevier
A novel series of P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) inhibitors with
triazol-N-phenethyl-tetrahydroisoquinoline or triazol-N-ethyl-tetrahydroisoquinoline scaffold …
triazol-N-phenethyl-tetrahydroisoquinoline or triazol-N-ethyl-tetrahydroisoquinoline scaffold …
Development of high-content imaging assays for lethal viral pathogens
RG Panchal, KP Kota, KB Spurgers… - Journal of …, 2010 - journals.sagepub.com
Filoviruses such as Ebola (EBOV) and Marburg (MARV) are single-stranded negative sense
RNA viruses that cause acute hemorrhagic fever with high mortality rates. Currently, there …
RNA viruses that cause acute hemorrhagic fever with high mortality rates. Currently, there …
[HTML][HTML] The contrasting catalytic efficiency and cancer cell antiproliferative activity of stereoselective organoruthenium transfer hydrogenation catalysts
Y Fu, C Sanchez-Cano, R Soni… - Dalton …, 2016 - pubs.rsc.org
The rapidly growing area of catalytic ruthenium chemistry has provided new complexes with
potential as organometallic anticancer agents with novel mechanisms of action. Here we …
potential as organometallic anticancer agents with novel mechanisms of action. Here we …
Ruthenium (II) polypyridyl complexes with benzothiophene and benzimidazole derivatives: Synthesis, antitumor activity, solution studies and biospeciation
O Dömötör, RG Teixeira, G Spengler, F Avecilla… - Journal of Inorganic …, 2023 - Elsevier
With the aim to incorporate pharmacophore motifs into the Ru (II)-polypyridyl framework,
compounds [Ru (II)(1, 10-phenantroline) 2 (2-(2-pyridyl) benzo [b] thiophene)](CF 3 SO 3) 2 …
compounds [Ru (II)(1, 10-phenantroline) 2 (2-(2-pyridyl) benzo [b] thiophene)](CF 3 SO 3) 2 …
3-Hydrazinoindolin-2-one derivatives: chemical classification and investigation of their targets as anticancer agents
Isatin is a well acknowledged pharmacophore in many clinically approved drugs used for
treatment of cancer. 3-Hydrazinoindolin-2-one, as a derivative of isatin, represents a …
treatment of cancer. 3-Hydrazinoindolin-2-one, as a derivative of isatin, represents a …
[HTML][HTML] Relation of metal-binding property and selective toxicity of 8-hydroxyquinoline derived Mannich bases targeting multidrug resistant cancer cells
Simple Summary Effective treatment of cancer is often limited by the resistance of cancer
cells to chemotherapy. A well-described mechanism supporting multidrug resistance (MDR) …
cells to chemotherapy. A well-described mechanism supporting multidrug resistance (MDR) …