Stress is associated with various epigenetic changes. Some stress-induced epigenetic
changes are highly dynamic, whereas others are associated with lasting marks on the …

Notwithstanding advances in understanding the pathophysiology of major depressive
disorder (MDD), no single mechanism can explain all facets of this disorder. An expanding …

Introduction Recent evidence from the studies evaluating the association between brain-
derived neurotrophic factor (BDNF) concentration/levels, BDNF Val66Met (rs6265) …

The effect of the intestinal microbiome on the gut–brain axis has received considerable
attention, strengthening the evidence that intestinal bacteria influence emotions and …

Background Several lines of evidence point to an interaction between genetic predisposition
and environmental factors in the onset of major depressive disorder (MDD). This study is …

Long-term psychosocial stress is strongly associated with negative physical and mental
health outcomes, as well as adverse health behaviours; however, little is known about the …

Depression is linked to stress which leaves traces in the epigenetic signature of genes. The
oxytocin system is implicated in allostatic processes promoting adaption to environmental …

Background Many studies have analyzed the association between family cohesion and
depression, but there are different views and the results are inconsistent. It is necessary to …

Depression is the most common mental disorder with a high treatment resistance rate that
can affect patients at any age. Individuals who obtain insufficient and unsatisfactory …

The gut microbiota is a complex and dynamic ecosystem known as the 'second brain'.
Composing the microbiota-gut-brain axis, the gut microbiota and its metabolites regulate the …