Zinc is an essential trace element, and anemia is the most common blood disorder. The
association of zinc with anemia may be divided into three major forms:(1) zinc deficiency …

Human erythropoietin (EPO) is an N-linked glycoprotein consisting of 166 aa that is
produced in the kidney during the adult life and acts both as a peptide hormone and …

Abstract 3D bioprinting strategies in tissue engineering aim to fabricate clinically applicable
tissue constructs that can replace the damaged or diseased tissues and organs. One of the …

In mammals, erythropoietin (EPO), produced in the kidney, is essential for bone marrow
erythropoiesis, and hypoxia induction of EPO production provides for the important …

Anemia is a major source of morbidity and mortality worldwide. Here we review recent
insights into how red blood cells (RBCs) are produced, the pathogenic mechanisms …

ABSTRACT Sickle Cell Anaemia (SCA) is one of the most prevalent monogenic disorders.
The formation of polymerized haemoglobin leading to erythrocyte rigidity and appearance of …

With the rapid development of nanotechnology, potential applications of nanomaterials in
medicine have been widely researched in recent years. Nanomaterials themselves can be …

Renal hypoxia occurs in acute kidney injury (AKI) of various etiologies. Activation of hypoxia-
inducible transcription factor (HIF) has been identified as an important mechanism of cellular …

More than 50 years of efforts to identify the major cytokine responsible for red blood cell
(RBC) production (erythropoiesis) led to the identification of erythropoietin (EPO) in 1977 …

We define a me‐too drug as a pharmacologically active compound that is structurally related
to a first‐in‐class compound, regarded as belonging to the same therapeutic class as the …