The severity and long-term consequences of brain damage in traumatic brain injured (TBI)
patients urgently calls for better neuroprotective/neuroreparative strategies for this …

Since their original discovery, type I interferons (IFN-Is) have been closely associated with
antiviral immune responses. However, their biological functions go far beyond this role, with …

Background Traumatic brain injury (TBI) is a leading cause of death and long-term disability
worldwide. In addition to primary brain damage, systemic immune alterations occur, with …

Abstract Alzheimer's disease (AD), the leading cause of dementia in older adults, is a double
proteinopathy characterized by amyloid-β (Aβ) and tau pathology. Despite enormous efforts …

Mild traumatic brain injury (mTBI) mostly causes transient symptoms, but repeated (r) mTBI
can lead to neurodegenerative processes. Diagnostic tools to evaluate the presence of …

The incidence of traumatic brain injury (TBI) increases dramatically with advanced age and
accumulating evidence indicates that age is one of the important predictors of an …

Traumatic brain injury (TBI) is a major cause of death and disability worldwide. Survivors
may experience movement disorders, memory loss, and cognitive deficits. However, there is …

Traumatic brain injury (TBI) is a major cause of disability and mortality worldwide,
particularly among the elderly, yet our mechanistic understanding of what renders the post …

The lectin pathway (LP) of complement mediates inflammatory processes linked to tissue
damage and loss of function following traumatic brain injury (TBI). LP activation triggers a …

The blood–brain barrier (BBB) is composed of brain microvasculature that provides selective
transport of solutes from the systemic circulation into the central nervous system to protect …