Leptomeningeal metastasis is a fatal manifestation seen in advanced cancer patients. Its
incidence is increasing, reaching 3.8% in molecularly unselected non-small cell lung cancer …

The presence of brain metastases (BM) is a negative prognostic factor for patients with
advanced nonsmall cell lung cancer (NSCLC). Their incidence seems to be higher in …

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Lung cancer has the highest frequency of brain dissemination compared to all other solid
tumours. Classical treatment options such as brain irradiation have started to be questioned …

With the use of EGFR TKIs, patient survival is now prolonged and as a consequence, a
higher chance of development of CNS metastases has been observed during the course of …

Clinical Question Is up-front whole-brain radiotherapy required to treat multiple brain
metastases from non–small-cell lung cancer when highly active targeted therapies are …

石 远凯 (Yuankai SHI), 1,* 孙 燕 (Yan SUN), 1 于 金明 (Jinming YU), 2 丁 翠敏 (Cuimin
DING), 3 马 智勇 (Zhiyong MA), 4 王 子平 (Ziping WANG), 5 王 东 (Dong WANG), 6 王 征 …

Background: The significance of uncommon epidermal growth factor receptor (EGFR)
mutations in patients with non-small cell lung cancer (NSCLC) and brain metastasis (BM) …

Here, we compare the relative clinical efficacy of EGFR-targeted tyrosine kinase inhibitors
(EGFR TKIs) for EGFR-positive advanced non-small-cell lung cancer (NSCLC). The authors …

Objectives Non-small cell lung cancer (NSCLC) with brain metastases (BM) is a challenging
clinical issue with poor prognosis. No data exist regarding extensive genetic analysis of …