Although over 90 independent risk variants have been identified for Parkinson's disease
using genome-wide association studies, most studies have been performed in just one …

Ageing phenotypes, such as years lived in good health (healthspan), total years lived
(lifespan), and survival until an exceptional old age (longevity), are of interest to us all but …

Functional annotation of genomes is a prerequisite for contemporary basic and applied
genomic research, yet farmed animal genomics is deficient in such annotation. To address …

An improved understanding of etiological mechanisms in Parkinson's disease (PD) is
urgently needed because the number of affected individuals is projected to increase rapidly …

Colocalization analysis has emerged as a powerful tool to uncover the overlapping of causal
variants responsible for both molecular and complex disease phenotypes. The findings from …

The rapid increase of omic data has greatly facilitated the investigation of associations
between omic profiles such as DNA methylation (DNAm) and complex traits in large cohorts …

Obesity and type 2 diabetes are causally related, yet there is considerable heterogeneity in
the consequences of both conditions and the mechanisms of action are poorly defined. Here …

Lymphatic metastasis is a crucial mechanism by which the cancer cells break away from the
primary (original) tumor and travel to the closest regional lymph node (s) and ultimately to …

Limited studies on multi-omics have been conducted to comprehensively investigate the
molecular mechanism underlying the developmental neurotoxicity of …

Leisure sedentary behaviours are associated with increased risk of cardiovascular disease,
but whether this relationship is causal is unknown. The aim of this study is to identify genetic …