Pre-metastatic niches: organ-specific homes for metastases
It is well established that organs of future metastasis are not passive receivers of circulating
tumour cells, but are instead selectively and actively modified by the primary tumour before …
tumour cells, but are instead selectively and actively modified by the primary tumour before …
Functional and biomimetic materials for engineering of the three-dimensional cell microenvironment
The cell microenvironment has emerged as a key determinant of cell behavior and function
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …
Matrix viscoelasticity promotes liver cancer progression in the pre-cirrhotic liver
Type 2 diabetes mellitus is a major risk factor for hepatocellular carcinoma (HCC). Changes
in extracellular matrix (ECM) mechanics contribute to cancer development,, and increased …
in extracellular matrix (ECM) mechanics contribute to cancer development,, and increased …
Matrix stiffness drives epithelial–mesenchymal transition and tumour metastasis through a TWIST1–G3BP2 mechanotransduction pathway
Matrix stiffness potently regulates cellular behaviour in various biological contexts. In breast
tumours, the presence of dense clusters of collagen fibrils indicates increased matrix …
tumours, the presence of dense clusters of collagen fibrils indicates increased matrix …
Silk fibroin for skin injury repair: where do things stand?
M Gholipourmalekabadi, S Sapru… - Advanced drug delivery …, 2020 - Elsevier
Several synthetic and natural materials are used in soft tissue engineering and regenerative
medicine with varying degrees of success. Among them, silkworm silk protein fibroin, a …
medicine with varying degrees of success. Among them, silkworm silk protein fibroin, a …
Extracellular matrix degradation and remodeling in development and disease
The extracellular matrix (ECM) serves diverse functions and is a major component of the
cellular microenvironment. The ECM is a highly dynamic structure, constantly undergoing a …
cellular microenvironment. The ECM is a highly dynamic structure, constantly undergoing a …
Extracellular matrix as an inductive scaffold for functional tissue reconstruction
BN Brown, SF Badylak - Translational Research, 2014 - Elsevier
The extracellular matrix (ECM) is a meshwork of both structural and functional proteins
assembled in unique tissue-specific architectures. The ECM both provides the mechanical …
assembled in unique tissue-specific architectures. The ECM both provides the mechanical …
Growth factors, matrices, and forces combine and control stem cells
Stem cell fate is influenced by a number of factors and interactions that require robust control
for safe and effective regeneration of functional tissue. Coordinated interactions with soluble …
for safe and effective regeneration of functional tissue. Coordinated interactions with soluble …
Collective cell guidance by cooperative intercellular forces
Cells comprising a tissue migrate as part of a collective. How collective processes are
coordinated over large multi-cellular assemblies has remained unclear, however, because …
coordinated over large multi-cellular assemblies has remained unclear, however, because …
Biophysical regulation of epigenetic state and cell reprogramming
TL Downing, J Soto, C Morez, T Houssin, A Fritz… - Nature materials, 2013 - nature.com
Biochemical factors can help reprogram somatic cells into pluripotent stem cells, yet the role
of biophysical factors during reprogramming is unknown. Here, we show that biophysical …
of biophysical factors during reprogramming is unknown. Here, we show that biophysical …