A review on the modernization of pharmaceutical development and manufacturing–Trends, perspectives, and the role of mathematical modeling
Recently, the pharmaceutical industry has been facing several challenges associated to the
use of outdated development and manufacturing technologies. The return on investment on …
use of outdated development and manufacturing technologies. The return on investment on …
Continuous crystallization processes in pharmaceutical manufacturing: A review
J Orehek, D Teslic, B Likozar - Organic Process Research & …, 2020 - ACS Publications
This scientific paper presents an overview of continuous solution crystallization in the
pharmaceutical industry. Since the specific knowledge spectrum of precipitation is very …
pharmaceutical industry. Since the specific knowledge spectrum of precipitation is very …
Continuous crystallization and its potential use in drug substance Manufacture: A review
Interest in the continuous manufacturing in the pharmaceutical industry for the production of
Active Pharmaceutical Ingredients (API's) has greatly increased in recent years. This has led …
Active Pharmaceutical Ingredients (API's) has greatly increased in recent years. This has led …
Integrated continuous pharmaceutical technologies—a review
Innovation in the pharmaceutical industry has been limited for a long time to the research
and development of new active compounds; meanwhile, the structure of the production …
and development of new active compounds; meanwhile, the structure of the production …
Population balance model enabled digital design and uncertainty analysis framework for continuous crystallization of pharmaceuticals using an automated platform …
A systematic digital design framework for the development of a digital twin of a continuous
crystallization process was presented using the model compound, diphenhydramine …
crystallization process was presented using the model compound, diphenhydramine …
Digital design of the crystallization of an active pharmaceutical ingredient using a population balance model with a novel size dependent growth rate expression. From …
B Szilagyi, A Eren, JL Quon… - Crystal Growth & …, 2021 - ACS Publications
Prediction and control of the product properties in crystallization processes are practical
challenges in the pharmaceutical industry. Effective crystallization process design and …
challenges in the pharmaceutical industry. Effective crystallization process design and …
Monitoring and digital design of the cooling crystallization of a high-aspect ratio anticancer drug using a two-dimensional population balance model
B Szilágyi, A Eren, JL Quon, CD Papageorgiou… - Chemical Engineering …, 2022 - Elsevier
The development of a process model for the batch cooling crystallization of an anticancer
drug from Takeda Pharmaceuticals is presented. The compound forms needle-like crystals …
drug from Takeda Pharmaceuticals is presented. The compound forms needle-like crystals …
Digital design of an integrated purification system for continuous pharmaceutical manufacturing
In this work dynamic models of the continuous crystallization, filtration, deliquoring, washing,
and drying steps are introduced, which are developed in the open-source pharmaceutical …
and drying steps are introduced, which are developed in the open-source pharmaceutical …
Targeting particle size specification in pharmaceutical crystallization: A review on recent process design and development strategies and particle size measurements
Obtaining a particle size within the specifications for a pharmaceutical compound in an
industrial crystallization can be a challenging task. The events affecting the final particle size …
industrial crystallization can be a challenging task. The events affecting the final particle size …
[HTML][HTML] Diastereomer salt crystallization: Comprehensive process modeling and DoE-driven comparison of custom-coded and user-friendly simulators
Process modeling is gaining attention in the pharmaceutical industry due to the promise of
exploring the design space with less experimentation. However, the associated numerical …
exploring the design space with less experimentation. However, the associated numerical …