[HTML][HTML] Drug resistance in liver flukes

I Fairweather, GP Brennan, REB Hanna… - International Journal for …, 2020 - Elsevier
Liver flukes include Fasciola hepatica, Fasciola gigantica, Clonorchis sinensis, Opisthorchis
spp., Fascioloides magna, Gigantocotyle explanatum and Dicrocoelium spp. The two main …

[HTML][HTML] Recent advances in candidate-gene and whole-genome approaches to the discovery of anthelmintic resistance markers and the description of drug/receptor …

AC Kotze, PW Hunt, P Skuce… - International Journal for …, 2014 - Elsevier
Anthelmintic resistance has a great impact on livestock production systems worldwide, is an
emerging concern in companion animal medicine, and represents a threat to our ongoing …

The Fasciola hepatica genome: gene duplication and polymorphism reveals adaptation to the host environment and the capacity for rapid evolution

K Cwiklinski, JP Dalton, PJ Dufresne, J La Course… - Genome biology, 2015 - Springer
Abstract Background The liver fluke Fasciola hepatica is a major pathogen of livestock
worldwide, causing huge economic losses to agriculture, as well as 2.4 million human …

Reducing the future threat from (liver) fluke: realistic prospect or quixotic fantasy?

I Fairweather - Veterinary parasitology, 2011 - Elsevier
The liver fluke remains an economically significant parasite of livestock and is emerging as
an important zoonotic infection of humans. The incidence of the disease has increased in …

Triclabendazole progress report, 2005–2009: an advancement of learning?

I Fairweather - Journal of helminthology, 2009 - cambridge.org
Triclabendazole (TCBZ) remains the drug of choice for treating infections of the liver fluke,
Fasciola hepatica in livestock and has become the main drug used to treat human cases of …

Fasciolosis in South America: epidemiology and control challenges

C Carmona, JF Tort - Journal of helminthology, 2017 - cambridge.org
Fasciolosis caused by Fasciola hepatica severely affects the efficiency of livestock
production systems worldwide. In addition to the economic impact inflicted on livestock …

A major locus confers triclabendazole resistance in Fasciola hepatica and shows dominant inheritance

NJ Beesley, K Cwiklinski, K Allen, RC Hoyle… - PLoS …, 2023 - journals.plos.org
Fasciola hepatica infection is responsible for substantial economic losses in livestock
worldwide and poses a threat to human health in endemic areas. The mainstay of control in …

Elucidating the transcriptome of Fasciola hepatica—a key to fundamental and biotechnological discoveries for a neglected parasite

ND Young, RS Hall, AR Jex, C Cantacessi… - Biotechnology …, 2010 - Elsevier
Liver flukes of animals are parasitic flatworms (Platyhelminthes: Digenea) of major
socioeconomic importance in many countries. Key representatives, such as Fasciola …

Comparative assessment of albendazole and triclabendazole ovicidal activity on Fasciola hepatica eggs

L Alvarez, G Moreno, L Moreno, L Ceballos… - Veterinary …, 2009 - Elsevier
The benzimidazole compounds albendazole (ABZ) and triclabendazole (TCBZ) are both
effective against Fasciola hepatica, although ABZ is only effective against adult flukes …

Liver fluke isolates: a question of provenance

I Fairweather - Veterinary parasitology, 2011 - Elsevier
A survey of literature on experimental infections with the liver fluke, Fasciola hepatica
published between 2005 and 2009 has revealed a general lack of information on where …