Current understanding of the physiopathology, diagnosis and therapeutic approach to Alzheimer's disease

V García-Morales, A González-Acedo… - Biomedicines, 2021 - mdpi.com
Alzheimer's disease (AD) is the most common cause of dementia. It is characterized by
cognitive decline and progressive memory loss. The aim of this review was to update the …

Magnetic resonance imaging studies of neurodegenerative disease: from methods to translational research

P Huang, M Zhang - Neuroscience Bulletin, 2023 - Springer
Neurodegenerative diseases (NDs) have become a significant threat to an aging human
society. Numerous studies have been conducted in the past decades to clarify their …

[HTML][HTML] Engineered macrophage-biomimetic versatile nanoantidotes for inflammation-targeted therapy against Alzheimer's disease by neurotoxin neutralization and …

M Cheng, C Ye, C Tian, D Zhao, H Li, Z Sun, Y Miao… - Bioactive Materials, 2023 - Elsevier
Immune recognition of excessive neurotoxins by microglia is a trigger for the onset of
neuroinflammation in the brain, leading to neurodegeneration in Alzheimer's disease (AD) …

The effect of swallowing action observation therapy on resting fMRI in stroke patients with dysphagia

M Zeng, Z Wang, X Chen, M Shi, M Zhu, J Ma… - Neural …, 2023 - Wiley Online Library
Objective. Many stroke victims have severe swallowing problems. Previous neuroimaging
studies have found that several brain regions scattered in the frontal, temporal, and parietal …

Non-invasive visualization of amyloid-beta deposits in Alzheimer amyloidosis mice using magnetic resonance imaging and fluorescence molecular tomography

W Ren, L Li, J Zhang, M Vaas, J Klohs… - Biomedical Optics …, 2022 - opg.optica.org
Abnormal cerebral accumulation of amyloid-beta peptide (Aβ) is a major hallmark of
Alzheimer's disease. Non-invasive monitoring of Aβ deposits enables assessing the disease …

Altered mitochondrial morphology and bioenergetics in a new yeast model expressing Aβ42

KK Epremyan, AG Rogov, TN Goleva… - International Journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is an incurable, age-related neurological disorder, the most
common form of dementia. Considering that AD is a multifactorial complex disease …

Current strategies of detecting Aβ species and inhibiting Aβ aggregation: Status and prospects

J Li, W Liao, D Huang, M Ou, T Chen, X Wang… - Coordination Chemistry …, 2023 - Elsevier
Alzheimer's disease (AD) is a central neurodegenerative disorder characterized by
behavioral disturbance and progressive cognitive impairment, and it is common in pre …

An adjustable amyloid-β oligomers aptasensor based on the synergistic effect of self-enhanced metal-organic gel luminophore and triple-helix DNA system

X Wang, R Chen, J Hu, W Yuan - International Journal of Biological …, 2022 - Elsevier
Amyloid-β oligomers (AβOs) was the core-biomarker of Alzheimer's disease (AD), and the
detection of AβOs is very important for the early diagnosis of AD. However, existing tests for …

A Near-infrared Fluorescence and Positron Emission Tomography Bimodal Probe for In Vivo Imaging of Amyloid-β Species

D Fang, D Pan, X Wen, J Zhang, M Yang… - ACS Chemical …, 2024 - ACS Publications
Noninvasive imaging of amyloid-β (Aβ) species in vivo is important for the early diagnosis of
Alzheimer's disease (AD). In this paper, we report a near-infrared (NIR) fluorescence (FL) …

Advances in nanoprobes for molecular MRI of Alzheimer's disease

P Parekh, AA Badachhape, EA Tanifum… - Wiley …, 2024 - Wiley Online Library
Alzheimer's disease is the most common cause of dementia and a leading cause of mortality
in the elderly population. Diagnosis of Alzheimer's disease has traditionally relied on …