Cardiovascular disease and thrombosis in HIV infection

MV Perkins, SB Joseph, DP Dittmer… - … , and vascular biology, 2023 - Am Heart Assoc
HIV infection has transitioned from an acute, fatal disease to a chronic one managed by
antiretroviral therapy. Thus, the aging population of people living with HIV (PLWH) continues …

HIV infection and coronary heart disease: mechanisms and management

PY Hsue, DD Waters - Nature Reviews Cardiology, 2019 - nature.com
Antiretroviral therapy has largely transformed HIV infection into a chronic disease condition.
As such, physicians and other providers caring for individuals living with HIV infection need …

[HTML][HTML] National Lipid Association recommendations for patient-centered management of dyslipidemia: part 2

TA Jacobson, KC Maki, CE Orringer, PH Jones… - Journal of clinical …, 2015 - Elsevier
Abstract An Expert Panel convened by the National Lipid Association previously developed
a consensus set of recommendations for the patient-centered management of dyslipidemia …

Systemic effects of inflammation on health during chronic HIV infection

SG Deeks, R Tracy, DC Douek - Immunity, 2013 - cell.com
Combination antiretroviral therapy for HIV infection improves immune function and
eliminates the risk of AIDS-related complications but does not restore full health. HIV …

Impact on life expectancy of HIV-1 positive individuals of CD4+ cell count and viral load response to antiretroviral therapy

MT May, M Gompels, V Delpech, K Porter, C Orkin… - Aids, 2014 - journals.lww.com
Objective: The objective of this study is to estimate life expectancies of HIV-positive patients
conditional on response to antiretroviral therapy (ART). Methods: Patients aged more than …

Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues

CV Fletcher, K Staskus, SW Wietgrefe… - Proceedings of the …, 2014 - National Acad Sciences
Antiretroviral therapy can reduce HIV-1 to undetectable levels in peripheral blood, but the
effectiveness of treatment in suppressing replication in lymphoid tissue reservoirs has not …

HIV-infected individuals with low CD4/CD8 ratio despite effective antiretroviral therapy exhibit altered T cell subsets, heightened CD8+ T cell activation, and increased …

S Serrano-Villar, T Sainz, SA Lee, PW Hunt… - PLoS …, 2014 - journals.plos.org
A low CD4/CD8 ratio in elderly HIV-uninfected adults is associated with increased morbidity
and mortality. A subset of HIV-infected adults receiving effective antiretroviral therapy (ART) …

Soluble markers of inflammation and coagulation but not T-cell activation predict non–AIDS-defining morbid events during suppressive antiretroviral treatment

AR Tenorio, Y Zheng, RJ Bosch… - The Journal of …, 2014 - academic.oup.com
Background. Defining the association of non–AIDS-defining events with inflammation and
immune activation among human immunodeficiency virus (HIV)–infected persons with …

Rising obesity prevalence and weight gain among adults starting antiretroviral therapy in the United States and Canada

JR Koethe, CA Jenkins, B Lau… - AIDS research and …, 2016 - liebertpub.com
The proportion of overweight and obese adults in the United States and Canada has
increased over the past decade, but temporal trends in body mass index (BMI) and weight …

Immunologic biomarkers, morbidity, and mortality in treated HIV infection

PW Hunt, SA Lee, MJ Siedner - The Journal of infectious …, 2016 - academic.oup.com
Despite marked improvements in the modern treatment era, human immunodeficiency virus
(HIV)–infected individuals, particularly those who initiated antiretroviral therapy (ART) at …