Lipids are essential metabolites, which function as energy sources, structural components
and signalling mediators. Most cells are able to convert carbohydrates into fatty acids, which …

The important role of mitochondria in the regulation of white adipose tissue (WAT)
remodeling and energy balance is increasingly appreciated. The remarkable heterogeneity …

Aims Vascular senescence, which is closely related to epigenetic regulation, is an early
pathological condition in cardiovascular diseases including atherosclerosis. Inhibition of S …

DNMT1 is the main enzyme that uses the information on DNA methylation patterns in the
parent strand and methylates the daughter strand in freshly replicated hemimethylated DNA …

Abstract Ten-eleven translocation (TET) 2 is an enzyme that catalyzes DNA demethylation to
regulate gene expression by oxidizing 5-methylcytosine to 5-hydroxymethylcytosine …

DNA methylation is a crucial epigenetic modification in the establishment of cell-type-
specific characteristics. However, how DNA methylation is selectively reprogrammed at …

The maintenance of epigenetic characteristics is essential for the normal growth and
development of organisms. The maintenance of DNA methylation is an important way to …

Air pollution has become one of the most serious health risks as a result of industrialization,
especially in developing countries. More attention has been drawn to the relationship …

Adipose tissue dysfunction is a hallmark of obesity and contributes to obesity-related
sequelae such as metabolic complications and insulin resistance. Compelling evidence …

The adipose organ is involved in many metabolic functions, ranging from the production of
endocrine factors to the regulation of thermogenic processes. Aging is a natural process that …