In-depth insights in cancer biology over the past decades have highlighted the important
roles of epigenetic mechanisms in the initiation and progression of tumorigenesis. The …

Cellular microRNAs (miRNAs) were identified as a key player in the posttranscriptional
regulation of cellular‐genes regulatory pathways. They also emerged as a significant …

The nucleosome acidic patch is a major interaction hub for chromatin, providing a platform
for enzymes to dock and orient for nucleosome-targeted activities. To define the molecular …

Simple Summary Previous clinical studies have suggested a relationship between
obstructive sleep apnea and some types of cancer. This relationship is very heterogeneous …

More than half a century ago, zinc was established as an essential micronutrient for normal
human physiology. In silico data suggest that about 10% of the human proteome potentially …

Epigenetic events like DNA methylation and histone modification can alter heritable
phenotypes. Zinc is required for the activity of various epigenetic enzymes, such as DNA …

Head and Neck Squamous Cell Carcinoma (HNSCC) is a highly heterogeneous group of
tumors characterized by an incidence of 650,000 new cases and 350,000 deaths per year …

Epigenetic regulation of gene expression is crucial to the determination of cell fate in
development and differentiation, and the Polycomb (PcG) and Trithorax (TrxG) groups of …

Heparan sulfate (HS) proteoglycans bind extracellular proteins that participate in cell
signaling, attachment and endocytosis. These interactions depend on the arrangement of …

Many natural products can exert anticancer or chemopreventive activity by interfering with
the cellular epigenetic machinery. Many studies indicate the relevance of affecting DNA …