Positional cloning and comprehensive mutation analysis identified a novel KDM2B mutation in a Japanese family with minor malformations, intellectual disability, and …
S Yokotsuka-Ishida, M Nakamura, Y Tomiyasu… - Journal of Human …, 2021 - nature.com
The importance of epigenetic control in the development of the central nervous system has
recently been attracting attention. Methylation patterns of lysine 4 and lysine 36 in histone …
recently been attracting attention. Methylation patterns of lysine 4 and lysine 36 in histone …
Mutation and expression alterations of histone methylation-related NSD2, KDM2B and SETMAR genes in colon cancers
SW Moon, HJ Son, HY Mo, EJ Choi, NJ Yoo… - Pathology-Research and …, 2021 - Elsevier
Epigenetic dysregulation is a hallmark of cancers, and examples of its cancer-associated
expression and mutation alterations are rapidly growing. Histone methylation, a process by …
expression and mutation alterations are rapidly growing. Histone methylation, a process by …
[HTML][HTML] Jumonji C demethylases in cellular senescence
KE Leon, KM Aird - Genes, 2019 - mdpi.com
Senescence is a stable cell cycle arrest that is either tumor suppressive or tumor promoting
depending on context. Epigenetic changes such as histone methylation are known to affect …
depending on context. Epigenetic changes such as histone methylation are known to affect …
Epigenetic regulation of chromatin in prostate cancer
Epigenetics refers to mitotically/meiotically heritable mechanisms that regulate gene
transcription without a need for changes in the DNA code. Covalent modifications of DNA, in …
transcription without a need for changes in the DNA code. Covalent modifications of DNA, in …
Transcription factors linked to the molecular signatures in the development of hepatocellular carcinoma on a cirrhotic background
J Motalebzadeh, E Eskandari - Medical Oncology, 2021 - Springer
Mechanisms underlying the regulation of gene expression in cancer have been surveyed for
decades to find novel prognostic factors and new targets for molecular targeted therapies in …
decades to find novel prognostic factors and new targets for molecular targeted therapies in …
Sevoflurane Confers Protection Against the Malignant Phenotypes of Lung Cancer Cells via the microRNA-153-3p/HIF1α/KDM2B Axis
K Xiong, Z Wu - Biochemical Genetics, 2023 - Springer
Sevoflurane is shown to curtail lung cancer (LC) development. Herein, this research sought
to investigate the underlying mechanism of sevoflurane in regard to its repressive effects on …
to investigate the underlying mechanism of sevoflurane in regard to its repressive effects on …
MicroRNA-211–5p in extracellular vesicles derived from BMSCs facilitates the repair of rat frozen shoulder via regulating KDM2B/LACC1 axis
X Mao, Z Li, S Gu, W Song, M Zhang, X Tan, Z Mao - Tissue and Cell, 2023 - Elsevier
Objective This study aims to explore the mechanism of miR-211–5p in extracellular vesicles
(EVs) derived from bone marrow mesenchymal stem cells (BMSCs) in improving frozen …
(EVs) derived from bone marrow mesenchymal stem cells (BMSCs) in improving frozen …
19q13. 12 KRAB zinc-finger protein ZNF383 represses p53 signaling pathway by interacting with p53
Y Liang, X Zhang, W Geng, Y Wang, Y Ding, Q Song… - Cellular …, 2022 - Elsevier
As one of the most important tumor suppressors, the activity of p53 is precisely regulated.
However, the mechanism of p53 regulation is still being elucidated and new regulatory …
However, the mechanism of p53 regulation is still being elucidated and new regulatory …
In silico analyses of the human sperm‐specific antigen 2 and its role in oral squamous cell carcinoma
Oral cancer is a serious threat to humans worldwide. The frequently diagnosed form of oral
cancer is oral squamous cell carcinoma (OSCC). The major etiologies of OSCC are the …
cancer is oral squamous cell carcinoma (OSCC). The major etiologies of OSCC are the …
An updated review on the significance of DNA and protein methyltransferases and de-methylases in human diseases: From molecular mechanism to novel therapeutic …
M Ghanbari, NS Khosroshahi, M Alamdar… - Current Medicinal …, 2023 - europepmc.org
Epigenetic mechanisms are crucial in regulating gene expression. These mechanisms
include DNA methylation and histone modifications, like methylation, acetylation, and …
include DNA methylation and histone modifications, like methylation, acetylation, and …