A review of current trends with type 2 diabetes epidemiology, aetiology, pathogenesis, treatments and future perspectives
J Reed, S Bain, V Kanamarlapudi - Diabetes, Metabolic Syndrome …, 2021 - Taylor & Francis
Abstract Type 2 diabetes (T2D), which has currently become a global pandemic, is a
metabolic disease largely characterised by impaired insulin secretion and action. Significant …
metabolic disease largely characterised by impaired insulin secretion and action. Significant …
[HTML][HTML] The molecular athlete: exercise physiology from mechanisms to medals
Human skeletal muscle demonstrates remarkable plasticity, adapting to numerous external
stimuli including the habitual level of contractile loading. Accordingly, muscle function and …
stimuli including the habitual level of contractile loading. Accordingly, muscle function and …
Lipotoxicity plays a key role in the development of both insulin resistance and muscle atrophy in patients with type 2 diabetes
RCR Meex, EE Blaak, LJC van Loon - Obesity Reviews, 2019 - Wiley Online Library
Insulin resistance and muscle mass loss often coincide in individuals with type 2 diabetes.
Most patients with type 2 diabetes are overweight, and it is well established that obesity and …
Most patients with type 2 diabetes are overweight, and it is well established that obesity and …
Moderate-intensity exercise and high-intensity interval training affect insulin sensitivity similarly in obese adults
Objective We compared the effects of high-intensity interval training (HIIT) and moderate-
intensity continuous training (MICT) on insulin sensitivity and other important metabolic …
intensity continuous training (MICT) on insulin sensitivity and other important metabolic …
Membrane fatty acid transporters as regulators of lipid metabolism: implications for metabolic disease
JFC Glatz, JJFP Luiken, A Bonen - Physiological reviews, 2010 - journals.physiology.org
Long-chain fatty acids and lipids serve a wide variety of functions in mammalian
homeostasis, particularly in the formation and dynamic properties of biological membranes …
homeostasis, particularly in the formation and dynamic properties of biological membranes …
PGC-1α regulation by exercise training and its influences on muscle function and insulin sensitivity
The peroxisome proliferator-activated receptor-γ (PPARγ) coactivator-1α (PGC-1α) is a
major regulator of exercise-induced phenotypic adaptation and substrate utilization. We …
major regulator of exercise-induced phenotypic adaptation and substrate utilization. We …
Muscle lipid metabolism: role of lipid droplets and perilipins
PE Morales, JL Bucarey… - Journal of diabetes …, 2017 - Wiley Online Library
Skeletal muscle is one of the main regulators of carbohydrate and lipid metabolism in our
organism, and therefore, it is highly susceptible to changes in glucose and fatty acid (FA) …
organism, and therefore, it is highly susceptible to changes in glucose and fatty acid (FA) …
Sprint interval and endurance training are equally effective in increasing muscle microvascular density and eNOS content in sedentary males
Key point Optimal vascular function is critical for health, and endurance training (ET) has
previously been shown to be an effective method of improving this. Sprint interval training …
previously been shown to be an effective method of improving this. Sprint interval training …
Restoration of muscle mitochondrial function and metabolic flexibility in type 2 diabetes by exercise training is paralleled by increased myocellular fat storage and …
RCR Meex, VB Schrauwen-Hinderling… - Diabetes, 2010 - Am Diabetes Assoc
OBJECTIVE Mitochondrial dysfunction and fat accumulation in skeletal muscle (increased
intramyocellular lipid [IMCL]) have been linked to development of type 2 diabetes. We …
intramyocellular lipid [IMCL]) have been linked to development of type 2 diabetes. We …
Effect of calorie restriction with or without exercise on insulin sensitivity, β-cell function, fat cell size, and ectopic lipid in overweight subjects
OBJECTIVE—The purpose of this article was to determine the relationships among total
body fat, visceral adipose tissue (VAT), fat cell size (FCS), ectopic fat deposition in liver …
body fat, visceral adipose tissue (VAT), fat cell size (FCS), ectopic fat deposition in liver …