Coeliac disease (CD) is a frequent immune enteropathy induced by gluten in genetically
predisposed individuals. Its pathogenesis has been extensively studied and CD has …

Owing to advances in genomics that enable differentiation of molecular aetiologies, patients
with monogenic inflammatory bowel disease (mIBD) potentially have access to genotype …

Scope Holothuria leucospilota polysaccharides (HLP) are bioactive polysaccharides with
immunomodulatory effects. This study aims to investigate the impact of HLP on dextran …

Variants in the UNC45A cochaperone have been recently associated with a syndrome
combining diarrhea, cholestasis, deafness, and bone fragility. Yet the mechanism underlying …

Nonresponsive celiac disease (CeD) is relatively common. It is generally attributed to
persistent gluten exposure and resolves after correction of diet errors. However, other …

STXBP2, encoding syntaxin-binding protein 2, is involved in intracellular organelle
trafficking and is associated with familial hemophagocytic lymphohistiocytosis type 5 …

Autoimmune enteropathy (AIE) is a severe form of enteropathy characterized by chronic
diarrhea refractory to any exclusion diet and associated with autoimmunity. 1, 2 Despite this …

Recently, the development of natural polysaccharides for ameliorating immunity and gut
metabolism has attracted extensive attention. This study used Holothuria leucospilota …

Crohn's disease (CD) and ulcerative colitis (UC) are both characterized by chronic
inflammation and severe dysfunction of the gastrointestinal tract. These two forms of …

溃疡性结肠炎(ulcerativecolitis, UC) 是一种发病机制尚不明确的慢性, 复发性炎症性疾病.
全球范围内, 其发病率及相关致死, 致残率持续上升, 造成了相当大的社会负担. 明确UC …