Immunopathogenesis and environmental triggers in coeliac disease
A Levescot, G Malamut, N Cerf-Bensussan - Gut, 2022 - gut.bmj.com
Coeliac disease (CD) is a frequent immune enteropathy induced by gluten in genetically
predisposed individuals. Its pathogenesis has been extensively studied and CD has …
predisposed individuals. Its pathogenesis has been extensively studied and CD has …
Precision medicine in monogenic inflammatory bowel disease: proposed mIBD REPORT standards
HH Uhlig, C Booth, J Cho, M Dubinsky… - Nature Reviews …, 2023 - nature.com
Owing to advances in genomics that enable differentiation of molecular aetiologies, patients
with monogenic inflammatory bowel disease (mIBD) potentially have access to genotype …
with monogenic inflammatory bowel disease (mIBD) potentially have access to genotype …
Microbiome–Metabolomics Analysis Reveals the Mechanism of Holothuria leucospilota Polysaccharides (HLP) in Ulcerative Colitis
X Zhang, K Zhu, S Zeng, Y Zheng… - Molecular Nutrition & …, 2023 - Wiley Online Library
Scope Holothuria leucospilota polysaccharides (HLP) are bioactive polysaccharides with
immunomodulatory effects. This study aims to investigate the impact of HLP on dextran …
immunomodulatory effects. This study aims to investigate the impact of HLP on dextran …
UNC45A deficiency causes microvillus inclusion disease–like phenotype by impairing myosin VB–dependent apical trafficking
R Duclaux-Loras, C Lebreton… - The Journal of …, 2023 - Am Soc Clin Investig
Variants in the UNC45A cochaperone have been recently associated with a syndrome
combining diarrhea, cholestasis, deafness, and bone fragility. Yet the mechanism underlying …
combining diarrhea, cholestasis, deafness, and bone fragility. Yet the mechanism underlying …
Advances in nonresponsive and refractory celiac disease
G Malamut, CR Soderquist, G Bhagat… - Gastroenterology, 2024 - Elsevier
Nonresponsive celiac disease (CeD) is relatively common. It is generally attributed to
persistent gluten exposure and resolves after correction of diet errors. However, other …
persistent gluten exposure and resolves after correction of diet errors. However, other …
Monogenic inflammatory bowel disease with STXBP2 mutations is not resolved by hematopoietic stem cell transplantation but can be alleviated via …
H Fujikawa, H Shimizu, R Nambu, I Takeuchi… - Clinical …, 2023 - Elsevier
STXBP2, encoding syntaxin-binding protein 2, is involved in intracellular organelle
trafficking and is associated with familial hemophagocytic lymphohistiocytosis type 5 …
trafficking and is associated with familial hemophagocytic lymphohistiocytosis type 5 …
[PDF][PDF] Genetic diagnosis guides treatment of autoimmune enteropathy
F Charbit-Henrion, M Haas, S Chaussade… - Clinical …, 2023 - Elsevier
Autoimmune enteropathy (AIE) is a severe form of enteropathy characterized by chronic
diarrhea refractory to any exclusion diet and associated with autoimmunity. 1, 2 Despite this …
diarrhea refractory to any exclusion diet and associated with autoimmunity. 1, 2 Despite this …
Holothuria leucospilota polysaccharides (HLP) ameliorate colitis rats via regulation of the metabolic profiling and TLR4/NLRP3 signaling pathways
X Zhang, Q Shi, M Hu, K Zhu, L Zhu, J Cao… - Food Frontiers, 2024 - Wiley Online Library
Recently, the development of natural polysaccharides for ameliorating immunity and gut
metabolism has attracted extensive attention. This study used Holothuria leucospilota …
metabolism has attracted extensive attention. This study used Holothuria leucospilota …
[HTML][HTML] Harnessing murine models of Crohn's disease ileitis to advance concepts of pathophysiology and treatment
L Iliopoulou, G Kollias - Mucosal immunology, 2022 - Elsevier
Crohn's disease (CD) and ulcerative colitis (UC) are both characterized by chronic
inflammation and severe dysfunction of the gastrointestinal tract. These two forms of …
inflammation and severe dysfunction of the gastrointestinal tract. These two forms of …
[PDF][PDF] 溃疡性结肠炎最新发病机制的认识
伍晓涵, 刘占举 - 中国中西医结合消化杂志, 2023 - zxyxhen.whuhzzs.com
溃疡性结肠炎(ulcerativecolitis, UC) 是一种发病机制尚不明确的慢性, 复发性炎症性疾病.
全球范围内, 其发病率及相关致死, 致残率持续上升, 造成了相当大的社会负担. 明确UC …
全球范围内, 其发病率及相关致死, 致残率持续上升, 造成了相当大的社会负担. 明确UC …