Apparent changes in the epidemiology and severity of multiple sclerosis

N Koch-Henriksen, M Magyari - Nature Reviews Neurology, 2021 - nature.com
Multiple sclerosis (MS) is an immunological disease that causes acute inflammatory lesions
and chronic inflammation in the CNS, leading to tissue damage and disability. As awareness …

Emerging pathogenic links between microbiota and the gut–lung axis

KF Budden, SL Gellatly, DLA Wood… - Nature Reviews …, 2017 - nature.com
The microbiota is vital for the development of the immune system and homeostasis.
Changes in microbial composition and function, termed dysbiosis, in the respiratory tract and …

Gender difference in oxidative stress: a new look at the mechanisms for cardiovascular diseases

MC Kander, Y Cui, Z Liu - Journal of cellular and molecular …, 2017 - Wiley Online Library
Gender differences are present in many diseases and are especially prevalent in
cardiovascular disease. Males tend to suffer from myocardial infarctions earlier than …

Incidence, prevalence, costs, and impact on disability of common conditions requiring rehabilitation in the United States: stroke, spinal cord injury, traumatic brain …

VY Ma, L Chan, KJ Carruthers - Archives of physical medicine and …, 2014 - Elsevier
Objective To determine the relative incidence, prevalence, costs, and impact on disability of
8 common conditions treated by rehabilitation professionals. Data Sources Comprehensive …

Autoimmune disease in women: endocrine transition and risk across the lifespan

MK Desai, RD Brinton - Frontiers in endocrinology, 2019 - frontiersin.org
Women have a higher incidence and prevalence of autoimmune diseases than men, and
85% or more patients of multiple autoimmune diseases are female. Women undergo …

Estrogens, neuroinflammation, and neurodegeneration

A Villa, E Vegeto, A Poletti, A Maggi - Endocrine reviews, 2016 - academic.oup.com
Inflammatory activation of microglia is a hallmark of several disorders of the central nervous
system. In addition to protecting the brain against inflammatory insults, microglia are …

Incidence and prevalence of multiple sclerosis in Europe: a systematic review

E Kingwell, JJ Marriott, N Jetté, T Pringsheim… - BMC neurology, 2013 - Springer
Background Multiple sclerosis (MS) is the most common cause of neurological disability in
young adults worldwide and approximately half of those affected are in Europe. The …

A meta-analysis of the epidemiology of giant cell arteritis across time and space

KJ Li, D Semenov, M Turk, J Pope - Arthritis research & therapy, 2021 - Springer
Introduction Giant cell arteritis (GCA) is a common large vessel vasculitis in those over age
50 years. This meta-analysis examined the geographical and temporal distribution of the …

Vitamin D and immunity in infants and children

G Mailhot, JH White - Nutrients, 2020 - mdpi.com
The last couple of decades have seen an explosion in our interest and understanding of the
role of vitamin D in the regulation of immunity. At the molecular level, the hormonal form of …

Multiple sclerosis: current knowledge and future outlook

CP Kamm, BM Uitdehaag, CH Polman - European neurology, 2014 - karger.com
Background: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous
system characterized by demyelination and axonal loss. The etiology of MS is unknown; …