All components of the CNS are surrounded by a diffuse extracellular matrix (ECM)
containing chondroitin sulphate proteoglycans (CSPGs), heparan sulphate proteoglycans …

A structural scaffold embedding brain cells and vasculature is known as extracellular matrix
(ECM). The physical appearance of ECM in the central nervous system (CNS) ranges from a …

Perineuronal nets (PNNs) surround specific neurons in the brain and are involved in various
forms of plasticity and clinical conditions. However, our understanding of the PNN role in …

Throughout early phases of brain development, the two main neural signaling mechanisms—
excitation and inhibition—are dynamically sculpted in the neocortex to establish primary …

Sex differences in motivation for food rewards, gambling, and drugs of abuse are modulated
by multiple factors, including sensory stimuli, gonadal hormones, and cognitive bias. Cues …

Stress-related psychiatric disorders including depression involve complex cellular and
molecular changes in the brain, and GABAergic signaling dysfunction is increasingly …

Overindulgence, excessive consumption, and a pattern of compulsive use of natural
rewards, such as certain foods or drugs of abuse, may result in the development of obesity …

Diffuse and structured extracellular matrix (ECM) comprise~ 20% of the brain's volume and
play important roles in development and adult plasticity. Perineuronal nets (PNNs) …

In Alzheimer's disease (AD), network hyperexcitability is frequently observed and associated
with subsequent cognitive impairment. Dysfunction of inhibitory interneurons (INs) is thought …

The consumption of synthetic cannabinoids during adolescence is reported to be a risk
factor for the appearance of psychiatric disorders later in life. JWH-018 was identified as one …