Long noncoding RNAs (lncRNAs) are an important class of pervasive genes involved in a
variety of biological functions. Here we discuss the emerging archetypes of molecular …

RNAs not encoding proteins have gained prominence over the last couple of decades as
fundamental regulators of cellular function. Not surprisingly, their dysregulation is …

The helicase RIG-I initiates an antiviral immune response after recognition of pathogenic
RNA. TRIM25, an E3 ubiquitin ligase, mediates K63-linked ubiquitination of RIG-I, which is …

Vast parts of mammalian genomes encode for transcripts that are not further translated into
proteins. The purpose of the majority of such noncoding ribonucleic acids (RNAs) remained …

Noncoding RNAs (ncRNAs) are classes of transcripts that are encoded by the genome and
transcribed but never get translated into proteins. Though not translated into proteins …

Telomere synthesis in cancer cells and stem cells involves trafficking of telomerase to Cajal
bodies, and telomerase is thought to be recruited to telomeres through interactions with …

Telomerase is a eukaryotic ribonucleoprotein (RNP) whose specialized reverse
transcriptase action performs de novo synthesis of one strand of telomeric DNA. The …

Genomes of complex organisms are characterized by the pervasive expression of different
types of noncoding RNAs (ncRNAs). lncRNAs constitute a large family of long—arbitrarily …

Cardiovascular disease is the leading cause of death in the United States, accounting for
nearly one in every seven deaths. Over the last decade, various targeted therapeutics have …

During aging, progressive deleterious changes increase the risk of disease and death.
Prominent molecular hallmarks of aging are genomic instability, telomere attrition …