Highlights•Monoclonal antibodies could be a viable alternative for resistant
infections.•Omics technologies can facilitate monoclonal antibody development.•Early-stage …

Sepsis is a life-threatening condition that arises when the body's response to an infection
injures its own tissues and organs. Despite significant morbidity and mortality throughout the …

Methods: In this multicenter prospective cohort trial, patients were assigned to the presepsin
or control groups. In the presepsin group, antibiotics were ceased based on predefined cut …

Background Sepsis is a life‐threatening disease for which critically important antimicrobials
(CIA) frequently are used. Diagnostic and therapeutic guidelines for sepsis and critically ill …

Objective The incidence of inappropriate and excessive empirical antibiotic therapy is
unclear. The aim of this study was to determine the prevalence of different empirical …

The evaluation and workup of fever and the use of antibiotics to treat infections is part of
daily practice in the surgical intensive care unit (ICU). Fever can be infectious or non …

Antibiotics are widely used for the treatment of bacterial infections. However, injudicious use
of antibiotics based on an empirical method may lead to the emergence of resistant strains …

As the field of interventional pain management (IPM) grows, the risk of surgical site
infections (SSIs) is increasing. SSI is defined as an infection of the incision or organ/space …

Previously characterized as a purely immune mediated disease, sepsis is now recognized
as a dysregulated multisystem response against a pathogen. Recognition of the infectious …

Background: Sepsis is deadly when not recognized and treated in a timely manner and
leads to 270,000 deaths each year in America. Mortality increases eight percent for each …