Fibrosis in adipose tissue is a major driver of obesity-related metabolic dysregulation. It is
characterized by an overaccumulation of extracellular matrix (ECM) during unhealthy …

Our overview covers several key areas related to recent results obtained for collagen type VI
and endotrophin (ETP).(1) An introduction to the history of ETP, including how it was …

Biochemistry of Collagens, Laminins, and Elastin: Structure, Function and Biomarkers, Third
Edition provides current data on key structural proteins (collagens, laminins, and elastin) …

Objective Renal fibrosis is a hallmark for chronic kidney disease (CKD), and often leads to
end stage renal disease (ESRD). However, limited interventions are available clinically to …

Extracellular matrix proteins harbor signaling domains that once released from the parent
molecule can trigger cellular responses. One of these molecules is endotrophin, a type VI …

Background and aims Extracellular matrix (ECM) homeostasis plays a crucial role in
metabolic plasticity and endocrine function of adipose tissue. High levels of intracellular …

Coronary artery disease (CAD) remains a leading cause of disease burden globally, and
there is a persistent need for new therapeutic targets. Instrumental variable (IV) and genetic …

Background: We evaluated the association between white adipose tissue parameters before
bariatric surgery (BS) and post-surgical weight loss, with an especial focus on extracellular …

Introduction There is an urgent, persistent, need for better biomarkers in clinical drug
development. More informative biomarkers can increase the likelihood of drug advancement …

Background. Kidney fibrosis is a suggested cause of kidney failure and premature mortality.
Because collagen type VI is closely linked to kidney fibrosis, we aimed to evaluate whether …