CD4+ T cells in cancer
Cancer immunology and immunotherapy are driving forces of research and development in
oncology, mostly focusing on CD8+ T cells and the tumor microenvironment. Recent …
oncology, mostly focusing on CD8+ T cells and the tumor microenvironment. Recent …
[HTML][HTML] Characterizing the dysfunctional NK cell: assessing the clinical relevance of exhaustion, anergy, and senescence
There is a growing body of literature demonstrating the importance of T cell exhaustion in
regulating and shaping immune responses to pathogens and cancer. Simultaneously, the …
regulating and shaping immune responses to pathogens and cancer. Simultaneously, the …
Metabolic reprogramming supports IFN-γ production by CD56bright NK cells
SE Keating, V Zaiatz-Bittencourt, RM Loftus… - The Journal of …, 2016 - journals.aai.org
Human NK cells can be classified into phenotypically and functionally distinct subsets based
on levels of CD56 receptor. CD56 dim cells are generally considered more cytotoxic …
on levels of CD56 receptor. CD56 dim cells are generally considered more cytotoxic …
[HTML][HTML] Cellular and molecular synergy in AS01-adjuvanted vaccines results in an early IFNγ response promoting vaccine immunogenicity
Combining immunostimulants in adjuvants can improve the quality of the immune response
to vaccines. Here, we report a unique mechanism of molecular and cellular synergy …
to vaccines. Here, we report a unique mechanism of molecular and cellular synergy …
[HTML][HTML] Innate immunity against HIV-1 infection
M Altfeld, M Gale Jr - Nature immunology, 2015 - nature.com
During acute HIV-1 infection, viral pathogen-associated molecular patterns are recognized
by pathogen-recognition receptors (PRRs) of infected cells, which triggers a signaling …
by pathogen-recognition receptors (PRRs) of infected cells, which triggers a signaling …
The common cytokine receptor γ chain family of cytokines
JX Lin, WJ Leonard - Cold Spring Harbor perspectives in …, 2018 - cshperspectives.cshlp.org
Interleukin (IL)-2, IL-4, IL-7, IL-9, IL-15, and IL-21 form a family of cytokines based on their
sharing the common cytokine receptor γ chain (γc), which was originally discovered as the …
sharing the common cytokine receptor γ chain (γc), which was originally discovered as the …
Interactions between innate and adaptive lymphocytes
G Gasteiger, AY Rudensky - Nature Reviews Immunology, 2014 - nature.com
Innate lymphocytes—including natural killer cells and the recently discovered innate
lymphoid cells—have crucial roles during infection, tissue injury and inflammation. Innate …
lymphoid cells—have crucial roles during infection, tissue injury and inflammation. Innate …
Bacillus Calmette–Guérin (BCG) revaccination of adults with latent Mycobacterium tuberculosis infection induces long-lived BCG-reactive NK cell responses
S Suliman, H Geldenhuys, JL Johnson… - The Journal of …, 2016 - journals.aai.org
One third of the global population is estimated to be latently infected with Mycobacterium
tuberculosis. We performed a phase I randomized controlled trial of isoniazid preventive …
tuberculosis. We performed a phase I randomized controlled trial of isoniazid preventive …
[HTML][HTML] Different adjuvants induce common innate pathways that are associated with enhanced adaptive responses against a model antigen in humans
W Burny, A Callegaro, V Bechtold, F Clement… - Frontiers in …, 2017 - frontiersin.org
To elucidate the role of innate responses in vaccine immunogenicity, we compared early
responses to hepatitis B virus (HBV) surface antigen (HBsAg) combined with different …
responses to hepatitis B virus (HBV) surface antigen (HBsAg) combined with different …
[HTML][HTML] Deciphering serology to understand the ecology of infectious diseases in wildlife
The ecology of infectious disease in wildlife has become a pivotal theme in animal and
public health. Studies of infectious disease ecology rely on robust surveillance of pathogens …
public health. Studies of infectious disease ecology rely on robust surveillance of pathogens …