The nucleus accumbens is a major input structure of the basal ganglia and integrates
information from cortical and limbic structures to mediate goal-directed behaviors. Chronic …

Aims Stimulant use disorder contributes to a substantial worldwide burden of disease,
although evidence-based treatment options are limited. This systematic review of reviews …

Rewards are both “liked” and “wanted,” and those 2 words seem almost interchangeable.
However, the brain circuitry that mediates the psychological process of “wanting” a particular …

Over the last 15 years, the field of neuroscience has evolved toward recognizing the critical
role of astroglia in shaping neuronal synaptic activity and along with the pre-and …

Complex roles for astrocytes in health and disease continue to emerge, highlighting this
class of cells as integral to function and dysfunction of the nervous system. In particular …

Drug-evoked plasticity at excitatory synapses on medium spiny neurons (MSNs) of the
nucleus accumbens (NAc) drives behavioral adaptations in addiction. MSNs expressing …

ABSTRACT Introduction: N-acetylcysteine (NAC) is widely known for its role as a mucolytic
and as an antidote to paracetamol overdose. There is increasing interest in the use of NAC …

An updated and expanded edition on the roles that brain function and genetics play in
addiction. Over the past 10 years, neurobiologic and genetic research has provided an …

Astrocytes provide support for neurons, regulate metabolic processes, and influence
neuronal communication in a variety of ways, including through the homeostatic regulation …

Drug addiction is a chronic, relapsing brain disorder. Multiple neural networks in the brain
including the reward system (eg, the mesocorticolimbic system), the anti-reward/stress …