[HTML][HTML] The role of the interleukin-36 axis in generalized pustular psoriasis: a review of the mechanism of action of spesolimab

JE Hawkes, S Visvanathan, JG Krueger - Frontiers in Immunology, 2023 - frontiersin.org
Generalized pustular psoriasis (GPP) is a rare, chronic, inflammatory skin disorder
characterized by recurrent flares associated with skin erythema, desquamation, and …

Use of biological therapies for the management of pustular psoriasis: a new era?

M Megna, E Camela, A Ruggiero… - Clinical, cosmetic and …, 2023 - Taylor & Francis
Generalized pustular psoriasis (GPP) is a severe and rare form of psoriasis, being a
potentially life-threatening condition, characterized by recurring episodes or flares of …

[HTML][HTML] Spesolimab for the treatment of generalized pustular psoriasis

D Bernardo, D Thaçi, T Torres - Drugs, 2024 - Springer
Generalized pustular psoriasis (GPP) is a rare but severe skin inflammatory disorder
characterized by the eruption of widespread sterile neutrophilic pustules, often accompanied …

Health‐related quality of life in patients with generalized pustular psoriasis: A systematic literature review

SE Choon, C De La Cruz, P Wolf… - Journal of the …, 2024 - Wiley Online Library
Generalized pustular psoriasis (GPP) is a rare, chronic, neutrophilic inflammatory skin
disease characterized by episodes of widespread eruption of sterile, macroscopic pustules …

Clinical advances in biological therapy for generalized pustular psoriasis: a review

CY Hsieh, TF Tsai - Expert Opinion on Biological Therapy, 2024 - Taylor & Francis
ABSTRACT Introduction In 2022, US Food and Drug Administration (FDA) approved the first
biologics, intravenous spesolimab, for acute flare of generalized pustular psoriasis (GPP) …

[HTML][HTML] Commentary: unmet needs in generalized pustular psoriasis in clinical practice

A Balato, F Ambrogio, M Burlando, CG Carrera… - Dermatology and …, 2024 - Springer
Generalized pustular psoriasis (GPP) is a rare and chronic inflammatory skin disease
characterized by recurrent flares of pustulation with or without systemic inflammation that …

Therapeutic Potential of Spesolimab-Sbzo in the Management of Generalized Pustular Psoriasis Flares in Adults: Evidence to Date

F Rega, F Trovato, G Bortone, G Pellacani… - … : Targets and Therapy, 2024 - Taylor & Francis
Generalized pustular psoriasis (GPP) is a rare, chronic, and severe skin disorder
characterized by the eruption of non-infectious pustules on an erythematous background …

Increased risk of severe generalized pustular psoriasis due to tuberculosis screening delay for spesolimab initiation

M Hackley, D Thampy, S Waseh, SR Feldman… - Journal of the American …, 2024 - Elsevier
Generalized pustular psoriasis (GPP) is a rare, potentially life-threatening pustular 39
dermatosis. Over half of patients with GPP require hospitalization, and the mortality rate due …

[HTML][HTML] Therapeutic Potential of IL-1 Antagonism in Hidradenitis Suppurativa

L Calabrese, D Malvaso, G Coscarella, F Antonelli… - Biomolecules, 2024 - mdpi.com
The immunopathogenesis of HS is partially understood and exhibits features of an
autoinflammatory disease; it is associated with the potential involvement of B cells and the …

[HTML][HTML] Generalized pustular psoriasis in a toddler with IL36RN mutation: a case report

G Adi, MR Shaath, K Adi, Z Obaid, E Aldosari… - Frontiers in …, 2024 - frontiersin.org
Generalized Pustular Psoriasis (GPP) is a dermatological autoinflammatory disease that
rarely occurs in children and is associated with complex genetic factors. GPP pathogenesis …