Influenza virus and SARS-CoV-2: pathogenesis and host responses in the respiratory tract
T Flerlage, DF Boyd, V Meliopoulos… - Nature Reviews …, 2021 - nature.com
Influenza viruses cause annual epidemics and occasional pandemics of respiratory tract
infections that produce a wide spectrum of clinical disease severity in humans. The novel …
infections that produce a wide spectrum of clinical disease severity in humans. The novel …
Extrapulmonary manifestations of COVID-19
A Gupta, MV Madhavan, K Sehgal, N Nair… - Nature medicine, 2020 - nature.com
Although COVID-19 is most well known for causing substantial respiratory pathology, it can
also result in several extrapulmonary manifestations. These conditions include thrombotic …
also result in several extrapulmonary manifestations. These conditions include thrombotic …
SARS-CoV-2 and viral sepsis: observations and hypotheses
Since the outbreak of coronavirus disease 2019 (COVID-19), clinicians have tried every
effort to understand the disease, and a brief portrait of its clinical features have been …
effort to understand the disease, and a brief portrait of its clinical features have been …
Cytokine storm—definition, causes, and implications
D Jarczak, A Nierhaus - International journal of molecular sciences, 2022 - mdpi.com
The human innate and adaptive immune systems consist of effector cells producing
cytokines (interleukins, interferons, chemokines, and numerous other mediators). Usually, a …
cytokines (interleukins, interferons, chemokines, and numerous other mediators). Usually, a …
SARS-CoV-2 infection pathogenesis is related to oxidative stress as a response to aggression
R Cecchini, AL Cecchini - Medical hypotheses, 2020 - Elsevier
Since the WHO declared COVID-19 a pandemic, a great effort has been made to understand
this serious disease. Thousands of studies are being devoted to understanding its …
this serious disease. Thousands of studies are being devoted to understanding its …
Molecular mechanisms of oxidative stress in asthma
C Michaeloudes, H Abubakar-Waziri, R Lakhdar… - Molecular aspects of …, 2022 - Elsevier
The lungs are exposed to reactive oxygen species oxygen (ROS) produced as a result of
inhalation of oxygen, as well as smoke and other air pollutants. Cell metabolism and the …
inhalation of oxygen, as well as smoke and other air pollutants. Cell metabolism and the …
[HTML][HTML] Longitudinal COVID-19 profiling associates IL-1RA and IL-10 with disease severity and RANTES with mild disease
Y Zhao, L Qin, P Zhang, K Li, L Liang, J Sun, B Xu… - JCI insight, 2020 - ncbi.nlm.nih.gov
BACKGROUND. Identifying immune correlates of COVID-19 disease severity is an urgent
need for clinical management, vaccine evaluation, and drug development. Here, we present …
need for clinical management, vaccine evaluation, and drug development. Here, we present …
Type III interferons disrupt the lung epithelial barrier upon viral recognition
Viral infections of the lower respiratory tract are a leading cause of mortality. Mounting
evidence indicates that most severe cases are characterized by aberrant immune responses …
evidence indicates that most severe cases are characterized by aberrant immune responses …
Interference between rhinovirus and influenza A virus: a clinical data analysis and experimental infection study
Background During the 2009 pandemic of an emerging influenza A virus (IAV;
H1N1pdm09), data from several European countries indicated that the spread of the virus …
H1N1pdm09), data from several European countries indicated that the spread of the virus …
Longitudinal changes of inflammatory parameters and their correlation with disease severity and outcomes in patients with COVID-19 from Wuhan, China
Abstract Background Coronavirus disease 2019 (COVID-19) is a newly emerging infectious
disease and rapidly escalating epidemic caused by the severe acute respiratory syndrome …
disease and rapidly escalating epidemic caused by the severe acute respiratory syndrome …