Research elucidating the pathogenesis of systemic lupus erythematosus (SLE) has defined
two critical families of mediators, type I interferon (IFN-I) and autoantibodies targeting nucleic …

C-reactive protein (CRP) is well-known as a sensitive albeit unspecific biomarker of
inflammation. In most rheumatic conditions, the level of this evolutionarily highly conserved …

Type I interferons (IFNs), mostly IFNα and IFNβ, and the type I IFN Signature are important in
the pathogenesis of Systemic Lupus Erythematosus (SLE), an autoimmune chronic …

Methylation of cytosine residues in DNA, the best studied epigenetic modification, is
associated with gene transcription and nuclear organization, and ultimately the function of a …

Background Type I interferons (IFN-I) contribute to a broad range of rheumatic and
musculoskeletal diseases (RMDs). Compelling evidence suggests that the measurement of …

Background Since the onset of the SARS-CoV-2 pandemic, most clinical testing has focused
on RT-PCR. Host epigenome manipulation post coronavirus infection,–suggests that DNA …

The pathogenesis of primary Sjögren's syndrome (pSS) remains poorly understood.
However, important efforts have been made during the last few months. In this review …

The major and upward trend in the number of published research related to rheumatic and
musculoskeletal diseases, in which artificial intelligence plays a key role, has exhibited the …

Objectives To systematically review the literature for assay methods that aim to evaluate type
I interferon (IFN-I) pathway activation and to harmonise-related terminology. Methods Three …

Primary Sjögren's syndrome (SS) is a systemic autoimmune disease characterized by
lymphocytic infiltration and damage of exocrine salivary and lacrimal glands. The etiology of …