[HTML][HTML] Human trials exploring anti-aging medicines

L Guarente, DA Sinclair, G Kroemer - Cell Metabolism, 2024 - cell.com
Here, we summarize the current knowledge on eight promising drugs and natural
compounds that have been tested in the clinic: metformin, NAD+ precursors, glucagon-like …

[HTML][HTML] Stress, epigenetics, and aging: unraveling the intricate crosstalk

Z Wu, J Qu, W Zhang, GH Liu - Molecular Cell, 2024 - cell.com
Aging, as a complex process involving multiple cellular and molecular pathways, is known to
be exacerbated by various stresses. Because responses to these stresses, such as oxidative …

The information theory of aging

YR Lu, X Tian, DA Sinclair - Nature aging, 2023 - nature.com
Abstract Information storage and retrieval is essential for all life. In biology, information is
primarily stored in two distinct ways: the genome, comprising nucleic acids, acts as a …

Chemical reprogramming for cell fate manipulation: methods, applications, and perspectives

J Wang, S Sun, H Deng - Cell Stem Cell, 2023 - cell.com
Chemical reprogramming offers an unprecedented opportunity to control somatic cell fate
and generate desired cell types including pluripotent stem cells for applications in …

Challenges in anti‐aging medicine–trends in biomarker discovery and therapeutic interventions for a healthy lifespan

I Popescu, J Deelen, M Illario… - Journal of Cellular and …, 2023 - Wiley Online Library
We are facing a growing aging population, along with increasing pressure on health
systems, caused by the impact of chronic co‐morbidities (ie cancer, cardiovascular and …

[HTML][HTML] Epigenetic reprogramming as a key to reverse ageing and increase longevity

B Pereira, FP Correia, IA Alves, M Costa… - Ageing research …, 2024 - Elsevier
The pursuit for the fountain of youth has long been a fascination amongst scientists and
humanity. Ageing is broadly characterized by a cellular decline with increased susceptibility …

The hallmarks of aging as a conceptual framework for health and longevity research

AG Tartiere, JMP Freije, C López-Otín - Frontiers in Aging, 2024 - frontiersin.org
The inexorability of the aging process has sparked the curiosity of human beings since
ancient times. However, despite this interest and the extraordinary scientific advances in the …

Relationship among α‑synuclein, aging and inflammation in Parkinson's disease

N Zhang, Z Yan, H Xin, S Shao… - Experimental and …, 2023 - spandidos-publications.com
Parkinson's disease (PD) is a common neurodegenerative pathology whose major clinical
symptoms are movement disorders. The main pathological characteristics of PD are the …

Noninvasive Techniques for Tracking Biological Aging of the Cardiovascular System: JACC Family Series

Z Raisi-Estabragh, L Szabo, A Schuermans… - Cardiovascular …, 2024 - jacc.org
Population aging is one of the most important demographic transformations of our time.
Increasing the “health span”—the proportion of life spent in good health—is a global priority …

Novel disulfidptosis‐derived gene blueprint stratifying patients with breast cancer

X Tang, B Ping, Y Liu, Y Zhou - Environmental Toxicology, 2024 - Wiley Online Library
Introduction Breast cancer remains the predominant cancer among females, accounting for
about 24.2% of all cancer cases. Alarmingly, it is the primary cause of cancer‐related …