[HTML][HTML] Human trials exploring anti-aging medicines
L Guarente, DA Sinclair, G Kroemer - Cell Metabolism, 2024 - cell.com
Here, we summarize the current knowledge on eight promising drugs and natural
compounds that have been tested in the clinic: metformin, NAD+ precursors, glucagon-like …
compounds that have been tested in the clinic: metformin, NAD+ precursors, glucagon-like …
[HTML][HTML] Stress, epigenetics, and aging: unraveling the intricate crosstalk
Aging, as a complex process involving multiple cellular and molecular pathways, is known to
be exacerbated by various stresses. Because responses to these stresses, such as oxidative …
be exacerbated by various stresses. Because responses to these stresses, such as oxidative …
The information theory of aging
Abstract Information storage and retrieval is essential for all life. In biology, information is
primarily stored in two distinct ways: the genome, comprising nucleic acids, acts as a …
primarily stored in two distinct ways: the genome, comprising nucleic acids, acts as a …
Chemical reprogramming for cell fate manipulation: methods, applications, and perspectives
J Wang, S Sun, H Deng - Cell Stem Cell, 2023 - cell.com
Chemical reprogramming offers an unprecedented opportunity to control somatic cell fate
and generate desired cell types including pluripotent stem cells for applications in …
and generate desired cell types including pluripotent stem cells for applications in …
Challenges in anti‐aging medicine–trends in biomarker discovery and therapeutic interventions for a healthy lifespan
We are facing a growing aging population, along with increasing pressure on health
systems, caused by the impact of chronic co‐morbidities (ie cancer, cardiovascular and …
systems, caused by the impact of chronic co‐morbidities (ie cancer, cardiovascular and …
[HTML][HTML] Epigenetic reprogramming as a key to reverse ageing and increase longevity
B Pereira, FP Correia, IA Alves, M Costa… - Ageing research …, 2024 - Elsevier
The pursuit for the fountain of youth has long been a fascination amongst scientists and
humanity. Ageing is broadly characterized by a cellular decline with increased susceptibility …
humanity. Ageing is broadly characterized by a cellular decline with increased susceptibility …
The hallmarks of aging as a conceptual framework for health and longevity research
AG Tartiere, JMP Freije, C López-Otín - Frontiers in Aging, 2024 - frontiersin.org
The inexorability of the aging process has sparked the curiosity of human beings since
ancient times. However, despite this interest and the extraordinary scientific advances in the …
ancient times. However, despite this interest and the extraordinary scientific advances in the …
Relationship among α‑synuclein, aging and inflammation in Parkinson's disease
N Zhang, Z Yan, H Xin, S Shao… - Experimental and …, 2023 - spandidos-publications.com
Parkinson's disease (PD) is a common neurodegenerative pathology whose major clinical
symptoms are movement disorders. The main pathological characteristics of PD are the …
symptoms are movement disorders. The main pathological characteristics of PD are the …
Noninvasive Techniques for Tracking Biological Aging of the Cardiovascular System: JACC Family Series
Population aging is one of the most important demographic transformations of our time.
Increasing the “health span”—the proportion of life spent in good health—is a global priority …
Increasing the “health span”—the proportion of life spent in good health—is a global priority …
Novel disulfidptosis‐derived gene blueprint stratifying patients with breast cancer
X Tang, B Ping, Y Liu, Y Zhou - Environmental Toxicology, 2024 - Wiley Online Library
Introduction Breast cancer remains the predominant cancer among females, accounting for
about 24.2% of all cancer cases. Alarmingly, it is the primary cause of cancer‐related …
about 24.2% of all cancer cases. Alarmingly, it is the primary cause of cancer‐related …