Stress is a critical environmental trigger for the development of clinical depression, yet little
is known about the specific neurobiological mechanisms by which stress influences the …

Glucocorticoid (GC), secreted by adrenal cortex, plays important roles in regulating many
physiological functions, while chronic stress level of GC exposure has many adverse effects …

Variation in stress responses has been investigated in relation to environmental factors,
species ecology, life history and fitness. Moreover, mechanistic studies have unravelled …

In the hippocampus, learning and memory are likely mediated by synaptic plasticity, known
as long-term potentiation (LTP). While chronic intermittent stress is negatively correlated …

We trained and tested young (6–8 months; n= 13), middle-aged (12–14 months; n= 41), and
aged (22–24 months; n= 24) male Fischer 344 rats in a rapid acquisition water maze task …

Nuclear receptor related‑1 protein (Nurr1) serves important roles in hippocampal‑dependent
cognitive process. In the present study, the protein expression of Nurr1 was compared in the …

Objectives: Given after traumatic brain injury (TBI), Dexamethasone (DXM) reduces cerebral
edema but impairs retrograde memory. This study was designed to test the hypothesis that …

目的观察左归丸和右归丸含药鼠血清对皮质酮所致大鼠海马神经细胞病理模型学习记忆相关
信号转导分子mRNA 表达的影响. 方法以新生24h 乳鼠海马组织为材料, 体外原代培养细胞 …

Some anticonvulsant drugs are associated with cognitive ability in patients; Topiramate
(TPM) is well known as an effective anticonvulsant agent applied in clinical settings …

目的探讨异氟醚麻醉对大鼠血皮质醇及海马脑源性神经营养因子(BDNF) 和神经生长因子(NGF)
的影响. 方法成年SD 雄性大鼠36 只, 10 周龄, 体重250~ 280g, 采用随机数字表法 …