The enhanced permeability retention effect: a new paradigm for drug targeting in infection

EA Azzopardi, EL Ferguson… - Journal of Antimicrobial …, 2013 - academic.oup.com
Multidrug-resistant, Gram-negative infection is a major global determinant of morbidity,
mortality and cost of care. The advent of nanomedicine has enabled tailored engineering of …

Kinin receptors in pain and inflammation

R Couture, M Harrisson, RM Vianna… - European journal of …, 2001 - Elsevier
Kinins are among the most potent autacoids involved in inflammatory, vascular and pain
processes. These short-lived peptides, including bradykinin, kallidin and T-kinin, are …

Angiotensin-converting enzyme II in the heart and the kidney

U Danilczyk, JM Penninger - Circulation research, 2006 - Am Heart Assoc
The renin-angiotensin system (RAS) has been recognized for many years as critical
pathway for blood pressure control and kidney functions. Although most of the well-known …

Neuropeptides: Potential neuroprotective agents in ischemic injury

P Saklani, H Khan, S Gupta, A Kaur, TG Singh - Life Sciences, 2022 - Elsevier
Aim Ischemic damage to the brain is linked to an increased rate of morbidity and mortality
worldwide. In certain parts of the world, it remains a leading cause of mortality and the …

[图书][B] Handbook of toxicology

MJ Derelanko, MA Hollinger - 2001 - api.taylorfrancis.com
LOCATE FREQUENTLY USED INFORMATION EASILY AND QUICKLYWorking in the
laboratory or office, you use a diverse assortment of basic information to design, conduct …

Angiotensin-converting enzyme and vascular remodeling

S Heeneman, JC Sluimer, MJAP Daemen - Circulation research, 2007 - Am Heart Assoc
Vascular remodeling is the result of a close interplay of changes in vascular tone and
structure. In this review, the role of angiotension-converting enzyme (ACE) and the impact of …

Recent advances in the pathophysiology and molecular basis of sepsis-associated organ dysfunction: novel therapeutic implications and challenges

Y Hattori, K Hattori, T Suzuki, N Matsuda - Pharmacology & therapeutics, 2017 - Elsevier
Sepsis is one of the most common reasons for critically ill patients to be admitted to an
intensive care unit and, despite advances in overall medical care, it represents a major …

Cardiac fibroblasts as sentinel cells in cardiac tissue: Receptors, signaling pathways and cellular functions

G Díaz-Araya, R Vivar, C Humeres, P Boza… - Pharmacological …, 2015 - Elsevier
Cardiac fibroblasts (CF) not only modulate extracellular matrix (ECM) proteins homeostasis,
but also respond to chemical and mechanical signals. CF express a variety of receptors …

Sphingosine 1-phosphate and control of vascular tone

APV Dantas, J Igarashi… - American Journal of …, 2003 - journals.physiology.org
Sphingosine-1-phosphate (S1P) is a platelet-derived lipid mediator that activates the
endothelial isoform of nitric oxide synthase (eNOS) in endothelial cells. However, the role of …

The kinin–kallikrein system: physiological roles, pathophysiology and its relationship to cancer biomarkers

E Kashuba, J Bailey, D Allsup, L Cawkwell - Biomarkers, 2013 - Taylor & Francis
The kinin–kallikrein system (KKS) is an endogenous multiprotein cascade, the activation of
which leads to triggering of the intrinsic coagulation pathway and enzymatic hydrolysis of …