The enhanced permeability retention effect: a new paradigm for drug targeting in infection
EA Azzopardi, EL Ferguson… - Journal of Antimicrobial …, 2013 - academic.oup.com
Multidrug-resistant, Gram-negative infection is a major global determinant of morbidity,
mortality and cost of care. The advent of nanomedicine has enabled tailored engineering of …
mortality and cost of care. The advent of nanomedicine has enabled tailored engineering of …
Kinin receptors in pain and inflammation
R Couture, M Harrisson, RM Vianna… - European journal of …, 2001 - Elsevier
Kinins are among the most potent autacoids involved in inflammatory, vascular and pain
processes. These short-lived peptides, including bradykinin, kallidin and T-kinin, are …
processes. These short-lived peptides, including bradykinin, kallidin and T-kinin, are …
Angiotensin-converting enzyme II in the heart and the kidney
U Danilczyk, JM Penninger - Circulation research, 2006 - Am Heart Assoc
The renin-angiotensin system (RAS) has been recognized for many years as critical
pathway for blood pressure control and kidney functions. Although most of the well-known …
pathway for blood pressure control and kidney functions. Although most of the well-known …
Neuropeptides: Potential neuroprotective agents in ischemic injury
Aim Ischemic damage to the brain is linked to an increased rate of morbidity and mortality
worldwide. In certain parts of the world, it remains a leading cause of mortality and the …
worldwide. In certain parts of the world, it remains a leading cause of mortality and the …
[图书][B] Handbook of toxicology
MJ Derelanko, MA Hollinger - 2001 - api.taylorfrancis.com
LOCATE FREQUENTLY USED INFORMATION EASILY AND QUICKLYWorking in the
laboratory or office, you use a diverse assortment of basic information to design, conduct …
laboratory or office, you use a diverse assortment of basic information to design, conduct …
Angiotensin-converting enzyme and vascular remodeling
S Heeneman, JC Sluimer, MJAP Daemen - Circulation research, 2007 - Am Heart Assoc
Vascular remodeling is the result of a close interplay of changes in vascular tone and
structure. In this review, the role of angiotension-converting enzyme (ACE) and the impact of …
structure. In this review, the role of angiotension-converting enzyme (ACE) and the impact of …
Recent advances in the pathophysiology and molecular basis of sepsis-associated organ dysfunction: novel therapeutic implications and challenges
Y Hattori, K Hattori, T Suzuki, N Matsuda - Pharmacology & therapeutics, 2017 - Elsevier
Sepsis is one of the most common reasons for critically ill patients to be admitted to an
intensive care unit and, despite advances in overall medical care, it represents a major …
intensive care unit and, despite advances in overall medical care, it represents a major …
Cardiac fibroblasts as sentinel cells in cardiac tissue: Receptors, signaling pathways and cellular functions
G Díaz-Araya, R Vivar, C Humeres, P Boza… - Pharmacological …, 2015 - Elsevier
Cardiac fibroblasts (CF) not only modulate extracellular matrix (ECM) proteins homeostasis,
but also respond to chemical and mechanical signals. CF express a variety of receptors …
but also respond to chemical and mechanical signals. CF express a variety of receptors …
Sphingosine 1-phosphate and control of vascular tone
APV Dantas, J Igarashi… - American Journal of …, 2003 - journals.physiology.org
Sphingosine-1-phosphate (S1P) is a platelet-derived lipid mediator that activates the
endothelial isoform of nitric oxide synthase (eNOS) in endothelial cells. However, the role of …
endothelial isoform of nitric oxide synthase (eNOS) in endothelial cells. However, the role of …
The kinin–kallikrein system: physiological roles, pathophysiology and its relationship to cancer biomarkers
E Kashuba, J Bailey, D Allsup, L Cawkwell - Biomarkers, 2013 - Taylor & Francis
The kinin–kallikrein system (KKS) is an endogenous multiprotein cascade, the activation of
which leads to triggering of the intrinsic coagulation pathway and enzymatic hydrolysis of …
which leads to triggering of the intrinsic coagulation pathway and enzymatic hydrolysis of …