Multidrug-resistant, Gram-negative infection is a major global determinant of morbidity,
mortality and cost of care. The advent of nanomedicine has enabled tailored engineering of …

Kinins are among the most potent autacoids involved in inflammatory, vascular and pain
processes. These short-lived peptides, including bradykinin, kallidin and T-kinin, are …

The renin-angiotensin system (RAS) has been recognized for many years as critical
pathway for blood pressure control and kidney functions. Although most of the well-known …

Aim Ischemic damage to the brain is linked to an increased rate of morbidity and mortality
worldwide. In certain parts of the world, it remains a leading cause of mortality and the …

LOCATE FREQUENTLY USED INFORMATION EASILY AND QUICKLYWorking in the
laboratory or office, you use a diverse assortment of basic information to design, conduct …

Vascular remodeling is the result of a close interplay of changes in vascular tone and
structure. In this review, the role of angiotension-converting enzyme (ACE) and the impact of …

Sepsis is one of the most common reasons for critically ill patients to be admitted to an
intensive care unit and, despite advances in overall medical care, it represents a major …

Cardiac fibroblasts (CF) not only modulate extracellular matrix (ECM) proteins homeostasis,
but also respond to chemical and mechanical signals. CF express a variety of receptors …

Sphingosine-1-phosphate (S1P) is a platelet-derived lipid mediator that activates the
endothelial isoform of nitric oxide synthase (eNOS) in endothelial cells. However, the role of …

The kinin–kallikrein system (KKS) is an endogenous multiprotein cascade, the activation of
which leads to triggering of the intrinsic coagulation pathway and enzymatic hydrolysis of …