Mesenchymal stromal/stem cells (MSCs) are multipotent adult stem cells that support
homeostasis during tissue regeneration. In the last decade, cell therapies based on the use …

Tissue regeneration from transplanted mesenchymal stromal cells (MSC) either through
transdifferentiation or cell fusion was originally proposed as the principal mechanism …

Mesenchymal stromal cells (MSCs) are heterogeneous and primitive cells discovered first in
the bone marrow (BM). They have putative roles in maintaining tissue homeostasis and are …

Background The therapeutic potential of mesenchymal stromal cells (MSCs) may be largely
mediated by paracrine factors contained in microvesicles (MV) released from intracellular …

Exosomes, a group of vesicles originating from the multivesicular bodies (MVBs), are
released into the extracellular space when MVBs fuse with the plasma membrane …

Mesenchymal stem cells (MSCs) are effective for the management of experimental ischemia-
reperfusion acute kidney injury (IRI-AKI). Immune modulation is one of the important …

Type 1 diabetes, has been recognized as an autoimmune disease. Like other
immunological conditions, regulation of immune response is a key strategy to control the …

Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by
the loss of immune tolerance. Lupus nephritis (LN) is still a major cause of the morbidity and …

The evolution of drug discovery exploded in the early 20th century with the advent of critical
scientific advancements in organic chemistry, chemical analysis, and purification. Early drug …

Cell repair/replacing strategies for neurodegenerative diseases such as Parkinson's disease
depend on well-characterized dopaminergic neuronal candidates that are healthy and show …