Obesity has tripled over the past 40 years to become a major public health issue, as it is
linked with increased mortality and elevated risk for various physical and neuropsychiatric …

Insulin acts on the CNS to modulate behaviour and systemic metabolism. Disturbances in
brain insulin action represent a possible link between metabolic and cognitive health …

Brain insulin action regulates eating behavior and energy fluxes throughout the body.
However, numerous people are brain insulin resistant. How brain insulin responsiveness …

Obesity has been variously linked to differences in brain functional connectivity in regions
associated with reward, emotional regulation and cognition, potentially revealing neural …

BACKGROUND Insulin resistance of the brain can unfavorably affect long-term weight
maintenance and body fat distribution. Little is known if and how brain insulin sensitivity can …

Overnutrition-related obesity has become a worldwide epidemic, and its prevalence is
expected to steadily rise in the future. It is widely recognized that obesity exerts negative …

In this paper, we propose that lithium may exert its therapeutic effect in bipolar disorder by
acting on insulin signaling pathways. Specifically, we assess the importance of the …

Accumulating evidence suggests that disrupted brain insulin signaling promotes the
development and progression of Alzheimer's disease (AD), driving clinicians to target this …

Cognitive impairment is a shared abnormality between type 2 diabetes mellitus (T2DM) and
many neurodegenerative and neuropsychiatric disorders, such as Alzheimer's disease (AD) …

Abstract Purpose of Review Dietary obesity is primarily attributed to an imbalance between
food intake and energy expenditure. Adherence to lifestyle interventions reducing weight is …