[HTML][HTML] Combination strategies with PD-1/PD-L1 blockade: current advances and future directions

M Yi, X Zheng, M Niu, S Zhu, H Ge, K Wu - Molecular cancer, 2022 - Springer
Antibodies targeting programmed cell death protein-1 (PD-1) or its ligand PD-L1 rescue T
cells from exhausted status and revive immune response against cancer cells. Based on the …

[HTML][HTML] Evolving landscape of PD-L2: bring new light to checkpoint immunotherapy

Y Wang, J Du, Z Gao, H Sun, M Mei, Y Wang… - British journal of …, 2023 - nature.com
Immune checkpoint blockade therapy targeting programmed cell death protein 1 (PD-1) has
revolutionized the landscape of multiple human cancer types, including head and neck …

Effect of first-line serplulimab vs placebo added to chemotherapy on survival in patients with extensive-stage small cell lung cancer: the ASTRUM-005 randomized …

Y Cheng, L Han, L Wu, J Chen, H Sun, G Wen, Y Ji… - Jama, 2022 - jamanetwork.com
Importance Programmed cell death ligand 1 inhibitors combined with chemotherapy has
changed the approach to first-line treatment in patients with extensive-stage small cell lung …

Adebrelimab or placebo plus carboplatin and etoposide as first-line treatment for extensive-stage small-cell lung cancer (CAPSTONE-1): a multicentre, randomised …

J Wang, C Zhou, W Yao, Q Wang, X Min… - The Lancet …, 2022 - thelancet.com
Background Extensive-stage small-cell lung cancer (ES-SCLC) is associated with poor
prognosis and treatment options are scarce. Immunotherapy has shown robust clinical …

[HTML][HTML] Synergistic efficacy of simultaneous anti-TGF-β/VEGF bispecific antibody and PD-1 blockade in cancer therapy

M Niu, M Yi, Y Wu, L Lyu, Q He, R Yang, L Zeng… - Journal of Hematology & …, 2023 - Springer
Background Recently, therapeutic antibodies against programmed cell death 1 (PD-1) and
its ligand (PD-L1) have exerted potent anticancer effect in a variety of tumors. However …

Camrelizumab plus apatinib as second-line treatment for advanced oesophageal squamous cell carcinoma (CAP 02): a single-arm, open-label, phase 2 trial

X Meng, T Wu, Y Hong, Q Fan, Z Ren, Y Guo… - The Lancet …, 2022 - thelancet.com
Background Camrelizumab, an anti-PD-1 antibody, has shown moderate efficacy in
oesophageal squamous cell carcinoma. Apatinib, a selective inhibitor of VEGFR2, has a …

Neoadjuvant chemoimmunotherapy for the treatment of locally advanced head and neck squamous cell carcinoma: a single-arm phase 2 clinical trial

Z Zhang, B Wu, G Peng, G Xiao, J Huang, Q Ding… - Clinical Cancer …, 2022 - AACR
Purpose: This study aimed to assess the antitumor activity and safety of neoadjuvant
chemotherapy combined with PD-1 inhibitor camrelizumab in patients with locally advanced …

Camrelizumab plus apatinib in patients with high-risk chemorefractory or relapsed gestational trophoblastic neoplasia (CAP 01): a single-arm, open-label, phase 2 …

H Cheng, L Zong, Y Kong, X Wang, Y Gu… - The Lancet …, 2021 - thelancet.com
Background Treatment options for patients with high-risk chemorefractory or relapsed
gestational trophoblastic neoplasia are scarce. The synergistic antitumour effect of …

[HTML][HTML] Angiogenesis inhibitors in small cell lung cancer

A Montanino, A Manzo, G Carillio, G Palumbo… - Frontiers in …, 2021 - frontiersin.org
Inhibition of angiogenesis has been demonstrated to be an efficacious strategy in treating
several tumors. Vascular endothelial growth factor (VEGF) is the most important protein with …

Multi‐target angiogenesis inhibitor combined with PD‐1 inhibitors may benefit advanced non‐small cell lung cancer patients in late line after failure of EGFR‐TKI …

L Yu, Y Hu, J Xu, R Qiao, H Zhong… - … Journal of Cancer, 2023 - Wiley Online Library
Treatments for NSCLC patients with EGFR‐TKI resistance are limited. Given that
immunotherapy and antiangiogenic agents may have synergistic antitumor effects, we …