Peptide‐mediated interactions (PMIs) play a crucial role in cell signaling network, which are
responsible for about half of cellular protein–protein associations in the human interactome …

Tumor necrosis factor (TNF-α) is capable of inducing apoptosis and is a promising candidate
for genetic engineering drugs in cancer therapy; however, the serious side-effects of TNF-α …

Cell signal networks are orchestrated directly or indirectly by various peptide-mediated
protein–protein interactions, which are normally weak and transient and thus ideal for …

Many cell signaling pathways are orchestrated by the weak, transient, and reversible protein–
protein interactions that are mediated by the binding of a short peptide segment in one …

Human angiotensin‐converting enzyme (ACE) is a well‐established druggable target for the
treatment of hypertension (HTN), which contains two structurally homologous but …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an etiological agent of
the current rapidly growing outbreak of coronavirus disease (COVID-19), which is straining …

Protein–peptide interactions (PpIs) play an important role in cell signaling networks and
have been exploited as new and attractive therapeutic targets. The affinity and specificity are …

Abstract Src homology 3 (SH3) domains are small protein modules involved in the
regulation of important cellular pathways such as proliferation and migration, which …

Self-binding peptide (SBP) represents a novel biomolecular phenomenon spanning
between folding and binding. It is a structurally independent, short peptide segment within a …

Ras Proteins, play a pivotal role in the proliferation pathways, and Ras mutant forms are well-
established cancer drivers. Ras mutations are found in about 30% of all human cancers …