Mesenchymal stromal cells (MSCs) are known to be widespread in many tissues and
possess a broad spectrum of immunoregulatory properties. They have been used in the …

Fibroblasts are non-hematopoietic structural cells that define the architecture of organs,
support the homeostasis of tissue-resident cells and play key roles in fibrosis, cancer …

Gut-draining mesenteric lymph nodes (mLN) provide the framework and microenvironment
to shape intestinal adaptive immune responses. We previously delineated transcriptional …

The immune system is vital in the protection and maintenance of the body in a healthy state
against extracellular pathogens, tissue injury and self-antigens (autoimmunity). Tertiary …

Resolving the mechanisms underlying bone formation would represent an important
advancement to our fundamental understanding of bone homeostasis. We have recently …

Notch is an evolutionarily conserved cell-to-cell signaling pathway with important roles
throughout biology that has emerged as a critical regulator of mature T cell responses …

The molecular mediators present within the inflammatory microenvironment are able, in
certain conditions, to favor the initiation of tertiary lymphoid structure (TLS) development …

1. Background 1.1 Lymphoma 1.2 Follicular lymphoma 1.3 Non-haematopoietic cells in
lymph nodes 2. Research objectives 3. Materials and methods 3.1 Human samples 3.2 …

Our understanding of splenic stromal cell composition and function remains incomplete.
Here, we uncover that splenic red pulp stroma is phenotypically Ly6C+ CD45+, due to …

The immunoglobulin-like domain containing receptor 2 (ILDR2), a type I transmembrane
protein belonging to the B7 family of immunomodulatory receptors, has been described to …