Obesity is a major health crisis affecting over a third of the global population. This
multifactorial disease is regulated via interoceptive neural circuits in the brain, whose …

Pituitary disease is associated with increased mortality predominantly due to vascular
disease. Control of cortisol secretion and GH hypersecretion (and cardiovascular risk factor …

Craniopharyngiomas are rare, mainly sellar/parasellar, epithelial tumors diagnosed during
childhood or adult life. Histologically, two primary subtypes have been recognized …

Glucocorticoids (GCs) are critical regulators of energy balance. Their deregulation is
associated with the development of obesity and metabolic syndrome. However, it is not …

Context: Stress-mediated hypothalamic-pituitary-adrenal axis activation, regulated by
arginine vasopressin (AVP), may have a role in the pathophysiology of metabolic syndrome …

Background Patients with hypothalamic pathology often develop morbid obesity, causing
severe metabolic alterations resulting in increased morbidity and mortality. Glucagon-like …

Obesity is a common complication after craniopharyngioma therapy, occurring in up to 75%
of survivors. Its weight gain is unlike that of normal obesity, in that it occurs even with caloric …

Objective Excessive weight gain frequently occurs in patients with hypothalamic tumors and
lesions leading to hypothalamic obesity (HO). Methods Digital brain magnetic resonance …

Objective Quality of life (QoL) is frequently impaired in childhood-onset craniopharyngioma
(CP) by hypothalamic syndrome. The debate, whether pretreatment hypothalamic …

Background Childhood obesity is a serious public health problem associated with the
development of several chronic diseases, such as type 2 diabetes mellitus, dyslipidemia …