The chemistry of reactive oxygen species (ROS) revisited: outlining their role in biological macromolecules (DNA, lipids and proteins) and induced pathologies

CA Juan, JM Pérez de la Lastra, FJ Plou… - International journal of …, 2021 - mdpi.com
Living species are continuously subjected to all extrinsic forms of reactive oxidants and
others that are produced endogenously. There is extensive literature on the generation and …

Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets

B Wang, L Wu, J Chen, L Dong, C Chen… - Signal transduction and …, 2021 - nature.com
The arachidonic acid (AA) pathway plays a key role in cardiovascular biology,
carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified …

[HTML][HTML] Futuristic food fortification with a balanced ratio of dietary ω-3/ω-6 omega fatty acids for the prevention of lifestyle diseases

A Patel, SS Desai, VK Mane, J Enman, U Rova… - Trends in Food Science …, 2022 - Elsevier
Background Over the last three decades, consumption of total and saturated fat has steadily
declined in Western diets as a proportion of calories intake. At the same time, omega (ω)-6 …

Dietary linoleic acid and human health: Focus on cardiovascular and cardiometabolic effects

F Marangoni, C Agostoni, C Borghi, AL Catapano… - Atherosclerosis, 2020 - Elsevier
This narrative review aims to discuss the more relevant evidence on the role of linoleic acid
(LA), a n-6 essential fatty acid that constitutes the predominant proportion of dietary …

Eicosanoids in inflammation in the blood and the vessel

A Yamaguchi, E Botta, M Holinstat - Frontiers in pharmacology, 2022 - frontiersin.org
Polyunsaturated fatty acids (PUFAs) are structural components of membrane phospholipids
in cells. PUFAs regulate cellular function through the formation of derived lipid mediators …

The role of arachidonic and linoleic acid derivatives in pathological pregnancies and the human reproduction process

M Szczuko, J Kikut, N Komorniak, J Bilicki… - International journal of …, 2020 - mdpi.com
The aim of the available literature review was to focus on the role of the proinflammatory
mediators of AA and LA derivatives in pathological conditions related to reproduction and …

[HTML][HTML] Curcumin and cardiovascular diseases: Focus on cellular targets and cascades

AM Pourbagher-Shahri, T Farkhondeh… - Biomedicine & …, 2021 - Elsevier
Cardiovascular diseases (CVDs) are one of the leading causes of the most considerable
mortality globally, and it has been tried to find the molecular mechanisms and design new …

Aerobic exercise training and gut microbiome-associated metabolic shifts in women with overweight: a multi-omic study

JE Hintikka, JP Ahtiainen, P Permi, S Jalkanen… - Scientific Reports, 2023 - nature.com
Physical activity is essential in weight management, improves overall health, and mitigates
obesity-related risk markers. Besides inducing changes in systemic metabolism, habitual …

Role of inflammatory processes in hemorrhagic stroke

SN Ohashi, JH DeLong, MG Kozberg, DJ Mazur-Hart… - Stroke, 2023 - Am Heart Assoc
Hemorrhagic stroke is the deadliest form of stroke and includes the subtypes of intracerebral
hemorrhage and subarachnoid hemorrhage. A common cause of hemorrhagic stroke in …

ALDH4A1 is an atherosclerosis auto-antigen targeted by protective antibodies

C Lorenzo, P Delgado, CE Busse, A Sanz-Bravo… - Nature, 2021 - nature.com
Cardiovascular disease (CVD) is the leading cause of mortality in the world, with most CVD-
related deaths resulting from myocardial infarction or stroke. The main underlying cause of …