From Ground-State to Excited-State Activation Modes: Flavin-Dependent “Ene”-Reductases Catalyzed Non-natural Radical Reactions
Conspectus Enzymes are desired catalysts for chemical synthesis, because they can be
engineered to provide unparalleled levels of efficiency and selectivity. Yet, despite the …
engineered to provide unparalleled levels of efficiency and selectivity. Yet, despite the …
Expanding chemistry through in vitro and in vivo biocatalysis
EN Kissman, MB Sosa, DC Millar, EJ Koleski… - Nature, 2024 - nature.com
Living systems contain a vast network of metabolic reactions, providing a wealth of enzymes
and cells as potential biocatalysts for chemical processes. The properties of protein and cell …
and cells as potential biocatalysts for chemical processes. The properties of protein and cell …
Chemoenzymatic Synthesis of Fluorinated L-α-Amino Acids
X Jin, C Huang, C Cui, H Liu, Z Liu… - ACS Sustainable …, 2024 - ACS Publications
Fluorinated amino acids play a crucial role as fundamental components in drug synthesis
owing to their favorable attributes that enhance the pharmacokinetic properties of drugs …
owing to their favorable attributes that enhance the pharmacokinetic properties of drugs …
Biocatalytic Generation of Trifluoromethyl Radicals by Nonheme Iron Enzymes for Enantioselective Alkene Difunctionalization
The trifluoromethyl (–CF3) group represents a highly prevalent functionality in
pharmaceuticals. Over the past few decades, significant advances have been made in the …
pharmaceuticals. Over the past few decades, significant advances have been made in the …
Radical-relay C (sp3)-H azidation catalyzed by an engineered nonheme iron enzyme
Q Zhao, J Rui, X Huang - Methods in enzymology, 2024 - pubmed.ncbi.nlm.nih.gov
Nonheme iron enzymes are versatile biocatalysts for a broad range of unique and powerful
transformations, such as hydroxylation, chlorination, and epimerization as well as …
transformations, such as hydroxylation, chlorination, and epimerization as well as …
Radical fluorine transfer catalysed by an engineered nonheme iron enzyme.
Q Zhao, Z Chen, J Rui, X Huang - Methods in Enzymology, 2024 - europepmc.org
Nonheme iron enzymes stand out as one of the most versatile biocatalysts for molecular
functionalization. They facilitate a wide array of chemical transformations within biological …
functionalization. They facilitate a wide array of chemical transformations within biological …