The DNA of all living organisms is persistently damaged by endogenous reactions including
deamination and oxidation. Such damage, if not repaired correctly, can result in mutations …

Early detection of cancer will improve survival rates. The blood biomarker 5-
hydroxymethylcytosine has been shown to discriminate cancer. In a large covariate …

DNA methylation is widely studied in the context of cancer. However, the rediscovery of 5-
hydroxymethylation of DNA adds a new layer of complexity to understanding the epigenetic …

The generation of gametes falls between two reprogramming phases. These phases are
characterised by profound periods of transcriptional activity, which define and reinforce …

The ability of DNA glycosylases to rapidly and efficiently detect lesions among a vast excess
of nondamaged DNA bases is vitally important in base excision repair (BER). Here, we use …

To decode the function and molecular recognition of several recently discovered cytosine
derivatives in the human genome–5‐hydroxymethylcytosine, 5‐formylcytosine, and 5 …

Drug screening assays employing organic fluorophores are widely used for high-throughput
screening of potential drugs. However, organic dyes generally possess short lifetimes and …

Developments in epigenomics, toxicology, and therapeutic nucleic acids all rely on a precise
understanding of nucleic acid properties and chemical reactivity. In this review we discuss …

5-hydroxymethylcytosine (5-hmC) was first detected in mammalian DNA five decades ago.
However, it did not take center stage in the field of epigenetics until 2009, when ten-eleven …

TET enzymes are the epigenetic factors involved in the formation of the sixth DNA base 5-
hydroxymethylcytosine, whose deregulation has been associated with tumorigenesis. In …